全芯活检系统与传统侧切口系统相比，能获取更大的肝组织样本且破碎率更低：一项随机试验。

Full-Core Biopsy Systems Take Larger Liver Tissue Samples with Lower Fragmentation Rates Than Conventional Side-Notch Systems: A Randomized Trial.

作者信息

Schaible Jan, Utpatel Kirsten, Verloh Niklas, Einspieler Ingo, Pregler Benedikt, Zeman Florian, Wiggermann Philipp, Schreyer Andreas G, Stroszczynski Christian, Beyer Lukas P

机构信息

Department of Radiology, University Medical Center Regensburg, Regensburg, Germany.

Institute of Pathology, University of Regensburg, Regensburg, Germany.

出版信息

Cancer Manag Res. 2020 Feb 13;12:1121-1128. doi: 10.2147/CMAR.S209824. eCollection 2020.

DOI:10.2147/CMAR.S209824

PMID:32104092

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7025653/

Abstract

BACKGROUND

The aim of this study was to compare the histopathological quality and physical features of the specimen of a full-core end-cut biopsy system with that of the standard side-notch system for liver biopsies.

METHODS

A full-core end-cut 16G biopsy device and a standard side-notch 16G needle were used to take biopsies of unclear liver lesions. Patients were randomized in two groups of 16 patients each. The primary endpoint of this prospective study was the core length measured using a dedicated microscope imaging software. Secondary endpoints were the quality of the specimen rated by an independent pathologist unaware of the device (scale from 1 to 5; with 1 as best and 5 as worst), the core diameter (determined by the microscopic imaging software) and presence of fragmentation (evaluated by the pathologist).

RESULTS

For the full-core (FC) and side-notch (SN) groups, the mean core length was similar with 13,599 μm and 11,570 μm (p=0.131), respectively. The quality of the specimen was significantly better in the FC-group with an average rating of 1.68 vs 2.50 (p=0.009). The fragmentation rate in the FC-group was statistically significantly lower at 2/27 (7%) than in the SN-group at 13/33 (39%) (p=0.021). The diameter in the FC-group was 1042 μm vs 930 μm in SN-group (p=0.018).

摘要

背景

本研究旨在比较全芯端切活检系统与标准侧切口系统用于肝活检时标本的组织病理学质量和物理特征。

方法

使用全芯端切16G活检装置和标准侧切口16G针，对不明肝脏病变进行活检。患者被随机分为两组，每组16例。这项前瞻性研究的主要终点是使用专用显微镜成像软件测量的芯长度。次要终点是由不了解所用设备的独立病理学家评定的标本质量（评分范围为1至5；1为最佳，5为最差）、芯直径（由显微镜成像软件确定）和碎片存在情况（由病理学家评估）。

结果

全芯（FC）组和侧切口（SN）组的平均芯长度相似，分别为13,599μm和11,570μm（p = 0.131）。FC组的标本质量明显更好，平均评分为1.68，而SN组为2.50（p = 0.009）。FC组的碎片率在统计学上显著低于SN组，分别为2/27（7%）和13/33（39%）（p = 0.021）。FC组的直径为1,042μm，而SN组为930μm（p = 0.018）。