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与多非利特过量及急性冠状动脉综合征同时出现的急性心电图改变

Acute Electrocardiographic Changes Coincident With Dofetilide Overdose and Acute Coronary Syndrome.

作者信息

King David J, Dutta Mudit, Goel Ramil, Xiang Kun

机构信息

Department of Medicine, University of Florida, Gainesville, Florida, USA.

VAMC and the University of Florida, Division of Cardiovascular Medicine, Gainesville, Florida, USA.

出版信息

JACC Case Rep. 2024 Nov 20;29(22):102709. doi: 10.1016/j.jaccas.2024.102709.

DOI:10.1016/j.jaccas.2024.102709
PMID:39691884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646880/
Abstract

A 73-year-old man with atrial fibrillation and coronary disease requiring stenting to the right coronary artery 7 months prior was admitted for observation after taking an extra dofetilide dose. Troponins trended upward, and electrocardiogram demonstrated QT prolongation to 502 ms as well as T-wave inversions. The patient underwent cardiac catheterization, which revealed severe distal left main disease.

摘要

一名73岁男性，患有心房颤动和冠状动脉疾病，7个月前需要对右冠状动脉进行支架植入，因多非利特剂量服用过量入院观察。肌钙蛋白呈上升趋势，心电图显示QT间期延长至502毫秒以及T波倒置。患者接受了心脏导管插入术，结果显示左主干远端严重病变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f834/11646880/e8fadc72b8ac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f834/11646880/a3322d47debe/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f834/11646880/e8fadc72b8ac/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f834/11646880/a3322d47debe/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f834/11646880/e8fadc72b8ac/gr1.jpg

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本文引用的文献

1
Prolongation of the QTc interval is seen uniformly during early transmural ischemia.在早期透壁性心肌缺血期间，QTc间期延长是普遍可见的。
J Am Coll Cardiol. 2007 Mar 27;49(12):1299-305. doi: 10.1016/j.jacc.2006.11.035. Epub 2007 Mar 9.
2
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development.多种药物的临床前心脏电生理学、临床QT间期延长与尖端扭转型室速之间的关系：药物研发中临时安全边际的证据
Cardiovasc Res. 2003 Apr 1;58(1):32-45. doi: 10.1016/s0008-6363(02)00846-5.
3
Dofetilide: a review of its use in atrial fibrillation and atrial flutter.
多非利特：其在心房颤动和心房扑动中应用的综述
Drugs. 1999 Dec;58(6):1043-59. doi: 10.2165/00003495-199958060-00007.