Feng Weiwei, Xie Xianjing, Su Yan, Jin Rong, Shi Wei
Department of Gynaecology and Obstetrics, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Key Laboratory of Embryo 0riginal Diseases, Shanghai, China.
Gynecol Endocrinol. 2024 Dec;40(1):2439886. doi: 10.1080/09513590.2024.2439886. Epub 2024 Dec 18.
This study aimed to analyze the correlation of adiponectin (APN) and leptin (LEP), reproductive endocrine hormones with insulin resistance (IR) in polycystic ovary syndrome (PCOS) patients with normal body mass index (BMI).
Totally 160 PCOS patients were categorized into the Normal BMI (BMI: 18.5-25 kg/m, = 62) and High BMI (BMI > 25 kg/m, = 98) groups. Glucose indicators [fasting plasma glucose, fasting insulin and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)], lipid indicators [total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)], adipokines [APN and LEP] and reproductive endocrine hormones [luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), total testosterone (TT), dehy-droepiandrosterone sulfate (DHEAS) and estradiol (E2)] were collected, and their correlations were analyzed. The relationship of HOMA-IR with APN, LEP and reproductive endocrine hormones was subjected to multiple linear regression analysis.
Correlation analysis revealed positive correlations of HOMA-IR with TC, TG, LDL-C, LEP, PRL, DHEAS and TT and negative correlations with HDL-C, APN, LH, FSH and E2 in PCOS patients with normal BMI. Multiple linear regression analysis showed that LH, FSH and E2 negatively affected HOMA-IR, while PRL positively affected HOMA-IR.
There were strong correlations of HOMA-IR in PCOS patients with normal BMI with APN, LEP, and reproductive endocrine hormones. Besides, LH, FSH, E2 and PRL expression had an important effect on IR in normal BMI PCOS patients, which provided a theoretical basis for the exploration of pathogenic mechanisms in normal BMI PCOS patients.
本研究旨在分析体重指数（BMI）正常的多囊卵巢综合征（PCOS）患者中脂联素（APN）、瘦素（LEP）、生殖内分泌激素与胰岛素抵抗（IR）之间的相关性。
将160例PCOS患者分为正常BMI组（BMI：18.5 - 25kg/m²，n = 62）和高BMI组（BMI > 25kg/m²，n = 98）。收集血糖指标[空腹血糖、空腹胰岛素及胰岛素抵抗稳态模型评估（HOMA - IR）]、血脂指标[总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL - C）和低密度脂蛋白胆固醇（LDL - C）]、脂肪因子[APN和LEP]及生殖内分泌激素[黄体生成素（LH）、卵泡刺激素（FSH）、催乳素（PRL）、总睾酮（TT）、硫酸脱氢表雄酮（DHEAS）和雌二醇（E2）]，并分析它们之间的相关性。对HOMA - IR与APN、LEP及生殖内分泌激素的关系进行多元线性回归分析。
相关性分析显示，BMI正常的PCOS患者中，HOMA - IR与TC、TG、LDL - C、LEP、PRL、DHEAS和TT呈正相关，与HDL - C、APN、LH、FSH和E2呈负相关。多元线性回归分析表明，LH、FSH和E2对HOMA - IR有负向影响，而PRL对HOMA - IR有正向影响。
BMI正常的PCOS患者中，HOMA - IR与APN、LEP及生殖内分泌激素密切相关。此外，LH、FSH、E2和PRL的表达对BMI正常的PCOS患者的IR有重要影响，这为探索BMI正常的PCOS患者的发病机制提供了理论依据。
