Le Hoang Mai, Querques Giuseppe, Guenoun Sacha, El Ghazi Djazia, Haddad Walid M, Mouallem Alexandra, Semoun Oudy, Souied Eric H
Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, University Paris Est Créteil, Créteil, France.
Department of Ophthalmology, San Raffaele Hospital, Milan, Italy.
Eur J Ophthalmol. 2025 Jul;35(4):1358-1365. doi: 10.1177/11206721241306225. Epub 2024 Dec 18.
PurposeTo report 8 cases of acute intra ocular inflammation (IOI) following intravitreal injections (IVI) of faricimab in patients with age related macular degeneration (AMD), retinal vein occlusion (RVO) and macular neovascularization associated with chronic central serous retinopathy (CSR).MethodsThis is a multicentric retrospective observational case-series. Cases of acute IOI that occurred in 5 different institutions in France and Italy between November 2023 and June 2024 were reported.Results8 eyes of 8 patients presented with acute IOI following IVI of faricimab. Best corrected visual acuity (BCVA) at the time of the IOI event varied between counting fingers and 20/25. 6 patients had neovascular AMD, 1 patient had a macular edema secondary to central RVO and 1 patient had a macular neovascularization associated with chronic CSR. Mean delay between the last IVI of faricimab and the assessment of the IOI event was 10.0 days. Presentation of IOI varied among patients. 6 patients presented with vitritis with varying severity. One of them had an associated papillitis. One patient presented with an anterior uveitis without vitritis. Corticosteroids were used in 5 cases. 2 cases resolved spontaneously. Surgery was needed in 1 case. These 8 cases of IOI occurred out of a total of 1923 IVI of faricimab performed with an estimated frequency of 0.41%.ConclusionAcute IOI may happen after IVI of faricimab. Severity of inflammation varies and treatment should be adjusted according to the clinical presentation.
目的报告8例年龄相关性黄斑变性（AMD）、视网膜静脉阻塞（RVO）以及与慢性中心性浆液性视网膜病变（CSR）相关的黄斑新生血管患者在玻璃体内注射法西单抗后发生急性眼内炎症（IOI）的情况。方法这是一项多中心回顾性观察病例系列研究。报告了2023年11月至2024年6月期间在法国和意大利5个不同机构发生的急性IOI病例。结果8例患者的8只眼在玻璃体内注射法西单抗后出现急性IOI。IOI事件发生时的最佳矫正视力（BCVA）在数指至20/25之间。6例患者患有新生血管性AMD，1例患者继发于中心性RVO的黄斑水肿，1例患者患有与慢性CSR相关的黄斑新生血管。法西单抗最后一次玻璃体内注射与IOI事件评估之间的平均间隔时间为10.0天。IOI的表现因患者而异。6例患者出现不同严重程度的葡萄膜炎。其中1例伴有视乳头炎。1例患者出现无前房葡萄膜炎的前葡萄膜炎。5例使用了皮质类固醇。2例自行缓解。1例需要手术治疗。这8例IOI发生在总共1923次法西单抗玻璃体内注射中，估计发生率为0.41%。结论玻璃体内注射法西单抗后可能发生急性IOI。炎症严重程度各不相同，应根据临床表现调整治疗。
