Mortimer J A, French L R, Hutton J T, Schuman L M
Neurology. 1985 Feb;35(2):264-7. doi: 10.1212/wnl.35.2.264.
A case-control study was performed in which the frequency of prior head injury was assessed in 78 patients with dementia of the Alzheimer type (DAT) and 124 control subjects matched for age, sex, and race. A history of head injury with loss of consciousness was reported in 25.6% of patients and 5.3% and 14.6% of hospital and neighborhood controls, respectively. Matched-pair analysis of patients and hospital controls yielded an odds ratio of 4.50, which was significant (p less than 0.01). The ranges of times of occurrence of head injuries were similar in patients and controls, spanning several decades. The findings suggest a possible etiologic role for head injury in DAT.
开展了一项病例对照研究，评估了78例阿尔茨海默型痴呆（DAT）患者及124名年龄、性别和种族相匹配的对照者既往头部受伤的频率。分别有25.6%的患者、5.3%的医院对照者和14.6%的社区对照者报告有伴意识丧失的头部受伤史。患者与医院对照者的配对分析得出优势比为4.50，具有显著性（p<0.01）。患者和对照者头部受伤发生时间的范围相似，跨越数十年。这些发现提示头部受伤在DAT中可能具有病因学作用。
