Maboudi Avideh, Eidi Milad, Lotfizadeh Anahita, Heidari Mohadeseh, Rafiei Alireza, Nabati Maryam, Moosazadeh Mahmood, Valadan Reza, Kardan Mostafa, Jabbareh Leila
Department of Periodontology, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Dent Med Probl. 2024 Nov-Dec;61(6):837-842. doi: 10.17219/dmp/169660.
Periodontitis is a chronic inflammatory disease of the supporting tissue surrounding the teeth. The disease is caused by specific bacteria, such as Porphyromonas gingivalis, which lead to the destruction of periodontal ligaments and alveolar bone.
The study aimed to evaluate the relationship between the prevalence of P. gingivalis in subgingival plaque and coronary artery disease (CAD).
Fifty patients with CAD and 50 healthy controls (non-CAD) participated in this case-control study. The periodontal health in the groups was evaluated through the assessment of the pocket depth (PD), clinical attachment loss (CAL) and bleeding on probing (BoP). The presence of P. gingivalis in subgingival plaque samples was determined through real-time polymerase chain reaction (RT-PCR). The data was analyzed using the χ2 test and the Mann-Whitney U test.
The mean PD was 3.30 ±1.55 mm and 3.56 ±0.97 mm in CAD patients and non-CAD subjects, respectively (p = 0.028). No significant differences were observed in the CAL (p = 0.858) and BoP (p = 1.000) between the groups. The RT-PCR results revealed the presence of P. gingivalis 16S rDNA in 32% and 22% of the subgingival plaque of patients with CAD and non-CAD, respectively, with a mean concentration of 7.7 × 106. No statistically significant association was observed between the prevalence of P. gingivalis and CAD (p = 0.260). The results of the multiple logistic regression analysis showed an association between CAD and male sex (p = 0.004, odds ratio (OR): 4.163), as well as age (p = 0.011, OR: 1.067).
The findings of this study indicated that there is no statistically significant correlation between the prevalence of P. gingivalis in subgingival plaque and CAD.
牙周炎是牙齿周围支持组织的一种慢性炎症性疾病。该疾病由特定细菌引起，如牙龈卟啉单胞菌，其会导致牙周韧带和牙槽骨的破坏。
本研究旨在评估龈下菌斑中牙龈卟啉单胞菌的患病率与冠状动脉疾病（CAD）之间的关系。
50例CAD患者和50例健康对照者（非CAD）参与了这项病例对照研究。通过评估牙周袋深度（PD）、临床附着丧失（CAL）和探诊出血（BoP）来评价各组的牙周健康状况。通过实时聚合酶链反应（RT-PCR）测定龈下菌斑样本中牙龈卟啉单胞菌的存在情况。使用χ2检验和曼-惠特尼U检验对数据进行分析。
CAD患者和非CAD受试者的平均PD分别为3.30±1.55mm和3.56±0.97mm（p = 0.028）。两组之间在CAL（p = 0.858）和BoP（p = 1.000）方面未观察到显著差异。RT-PCR结果显示，CAD患者和非CAD患者的龈下菌斑中分别有32%和22%存在牙龈卟啉单胞菌16S rDNA，平均浓度为7.7×106。牙龈卟啉单胞菌的患病率与CAD之间未观察到统计学上的显著关联（p = 0.260）。多元逻辑回归分析结果显示CAD与男性性别（p = 0.004，比值比（OR）：4.163）以及年龄（p = 0.011，OR：1.067）之间存在关联。
本研究结果表明，龈下菌斑中牙龈卟啉单胞菌的患病率与CAD之间不存在统计学上的显著相关性。
