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泌尿妇科网片取出术中的围手术期阿片类药物使用

Perioperative Opioid Use in Urogynecologic Mesh Removal.

作者信息

Artsen Amanda M, Gichuru Roseanne, Bonidie Michael, Giugale Lauren, Moalli Pamela A

机构信息

From the Magee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences at Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA.

Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh Medical Center Bedford Memorial Hospital, Everett.

出版信息

Urogynecology (Phila). 2025 Jan 1;31(1):18-25. doi: 10.1097/SPV.0000000000001527.

Abstract

IMPORTANCE

Forty percent of patients with urogynecologic mesh pain complications are taking narcotics.

OBJECTIVES

We aimed to compare comorbidities and pain scores between patients with and without narcotic use and assess postoperative narcotic use rates.

STUDY DESIGN

This was a secondary analysis of a prospective cohort study of patients undergoing urogynecologic mesh removal. Patients with mesh removal for pain within 7 years were included due to data availability. Narcotic prescriptions were verified using the Pennsylvania Prescription Drug Monitoring Program. Pain scores were assessed at baseline and 6-24 months postoperatively.

RESULTS

Of 139 patients, 30 (21.6%) filled narcotic prescriptions within 3 months preceding surgery. These patients were younger and more likely to have a chronic pain condition. Narcotic use did not differ by sling versus prolapse mesh, or presence of exposure. Patients taking preoperative narcotics had a 27-point higher median baseline visual analog scale pelvic pain score (P = 0.01). Patients with pain comorbidities had 6 times odds of using preoperative narcotics. Younger patients had less improvement in pelvic pain after removal. Only 8 (27%) of those taking narcotics discontinued use postoperatively with no significant predictors of prolonged (≥3 months) use. Eighty-seven percent of patients with prolonged postoperative use had a prior pain diagnosis, commonly joint and back pain.

CONCLUSIONS

In patients with mesh-related pain, those with chronic pain conditions had much higher odds of taking preoperative narcotics, and in most, mesh removal did not eliminate narcotic use. Counseling is warranted in patients with chronic pain conditions that pain and narcotic use are likely to persist after removal.

摘要

重要性

40%的有泌尿妇科网片疼痛并发症的患者正在服用麻醉药品。

目的

我们旨在比较使用和未使用麻醉药品的患者之间的合并症和疼痛评分,并评估术后麻醉药品使用率。

研究设计

这是一项对接受泌尿妇科网片取出术患者的前瞻性队列研究的二次分析。由于数据可得性,纳入了在7年内因疼痛而进行网片取出的患者。使用宾夕法尼亚州处方药监测计划核实麻醉药品处方。在基线和术后6至24个月评估疼痛评分。

结果

在139名患者中,30名(21.6%)在手术前3个月内开具了麻醉药品处方。这些患者更年轻,更有可能患有慢性疼痛疾病。麻醉药品的使用在吊带网片与盆腔器官脱垂网片之间或有无暴露情况方面没有差异。术前服用麻醉药品的患者基线视觉模拟量表盆腔疼痛评分中位数高27分(P = 0.01)。有疼痛合并症的患者术前使用麻醉药品的几率是6倍。年轻患者在取出网片后盆腔疼痛改善较少。服用麻醉药品的患者中只有8名(27%)术后停止使用,且没有延长使用(≥3个月)的显著预测因素。术后长期使用麻醉药品的患者中87%有先前的疼痛诊断,常见的是关节和背痛。

结论

在有网片相关疼痛的患者中,患有慢性疼痛疾病的患者术前服用麻醉药品的几率要高得多,而且在大多数情况下,取出网片并不能消除麻醉药品的使用。对于患有慢性疼痛疾病的患者,有必要进行咨询,告知其取出网片后疼痛和麻醉药品使用可能会持续。

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本文引用的文献

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Opioid use following pelvic reconstructive surgery: a predictive calculator.盆腔重建术后阿片类药物使用:预测计算器。
Int Urogynecol J. 2023 Aug;34(8):1725-1742. doi: 10.1007/s00192-022-05428-7. Epub 2023 Jan 28.
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Expanding Current Approaches to Solve the Opioid Crisis.拓展解决阿片类药物危机的现有方法。
JAMA Psychiatry. 2022 Jan 1;79(1):5-6. doi: 10.1001/jamapsychiatry.2021.3136.
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Postoperative Analgesia in the Chronic Pain Patient.慢性疼痛患者的术后镇痛。
Otolaryngol Clin North Am. 2020 Oct;53(5):843-852. doi: 10.1016/j.otc.2020.05.013. Epub 2020 Jul 20.

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