Liu Si-Xuan, Dai Si-Yang, Lu Yong-Fu, Guo Chun-Lin, Li Chang, Yang Yi-Hui, Pei Yue-Hu
Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150086, China.
J Asian Nat Prod Res. 2025 May;27(5):669-676. doi: 10.1080/10286020.2024.2431813. Epub 2024 Dec 18.
Three meroterpenoids, including one new compound, ranhuadujuanine E (), one new natural product, methyl ()-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (), and one known compound, ranhuadujuanine D (), along with two known sesquiterpenoids (-) were isolated from . Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of C-6' in compound was assigned by using Snatzke's method. Compounds - had inhibitory effects on LPS-induced NO release in RAW264.7 cells.
从[具体来源]中分离出三种半萜类化合物，包括一种新化合物——髯花杜鹃宁E（）、一种新天然产物——（）-3-(3,7-二甲基辛-2,6-二烯-1-基)-2,4-二羟基-6-甲基苯甲酸甲酯（）、一种已知化合物——髯花杜鹃宁D（），以及两种已知倍半萜（-）。通过广泛的光谱分析阐明了它们的结构，并使用施纳茨克方法确定了化合物中C-6'的绝对构型。化合物-对RAW264.7细胞中脂多糖诱导的一氧化氮释放具有抑制作用。
