Pei Bo, Liu Peijun, Peng Shixuan, Zhou Fuxiang
Department of Oncology, Hubei Provincial Clinical Research Center for Cancer, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Oncology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, China.
Discov Oncol. 2024 Dec 18;15(1):795. doi: 10.1007/s12672-024-01639-0.
Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).
We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods. Genome-wide association studies (GWAS) datasets for HPV were obtained from the IEU Open GWAS project. A large summary of colorectal adenocarcinoma and colorectal cancer data from the FinnGen database was used as the outcome.
Our analysis revealed a significant association between genetically predicted HPV-16 infection and the risk of paternal colorectal adenocarcinoma (HPV-16: OR 1.058, 95% CI 1.013-1.102; p = 0.011), as well as CRC (HPV-16: OR 1.045, 95% CI 1.005-1.085; p = 0.025).
These findings provide compelling evidence for a causal effect of HPV infection on the development of CRC. Further investigations into the underlying mechanisms and elucidation of this association are necessary to identify viable interventions for the prevention and treatment of HPV-associated CRC.
导致多种疾病的人乳头瘤病毒（HPV）感染是一个全球公共卫生问题。尽管HPV感染与宫颈癌和肛门生殖器癌之间的联系已得到充分证实，但关于HPV感染与结直肠癌（CRC）之间的关系仍存在争议。
我们使用五种孟德尔随机化（MR）方法评估了HPV感染与CRC之间的因果关系。HPV的全基因组关联研究（GWAS）数据集来自IEU开放GWAS项目。来自芬兰基因数据库的大量结直肠腺癌和结直肠癌数据汇总用作结果。
我们的分析显示，基因预测的HPV-16感染与父系结直肠腺癌风险之间存在显著关联（HPV-16：优势比1.058，95%置信区间1.013-1.102；p = 0.011），以及与CRC之间也存在显著关联（HPV-16：优势比1.045，95%置信区间1.005-1.085；p = 0.025）。
这些发现为HPV感染对CRC发生的因果效应提供了有力证据。有必要进一步研究其潜在机制并阐明这种关联，以确定预防和治疗HPV相关CRC的可行干预措施。
