B族维生素与衰老

B Vitamins and Ageing.

作者信息

Mikkelsen Kathleen, Apostolopoulos Vasso

机构信息

Institute for Health and Sport, Victoria University, Werribee, VIC, Australia.

出版信息

Subcell Biochem. 2018;90:451-470. doi: 10.1007/978-981-13-2835-0_15.

DOI:10.1007/978-981-13-2835-0_15

PMID:30779018

Abstract

Vitamin B contributes to the overall health and wellbeing, including that of energy metabolism, methylation, synthesis and DNA repair and proper immune function. Deficiency in B vitamins has been linked to neurocognitive disorders, mitochondrial dysfunction, immune dysfunction and inflammatory conditions. In ageing populations B vitamin deficiency has been linked to cardiovascular disorders, cognitive dysfunction, osteoporosis and methylation disorders and can increase the risk of developing degenerative diseases, particularly cardiovascular disease, cognitive diseases and osteoporosis. Optimization of B vitamin status in the elderly may prove beneficial in the prevention of degenerative diseases. Here we discuss broadly the role of B vitamins in ageing.

摘要

维生素B有助于整体健康和幸福，包括能量代谢、甲基化、合成及DNA修复以及正常免疫功能。维生素B缺乏与神经认知障碍、线粒体功能障碍、免疫功能障碍和炎症状态有关。在老年人群中，维生素B缺乏与心血管疾病、认知功能障碍、骨质疏松症和甲基化紊乱有关，并且会增加患退行性疾病的风险，尤其是心血管疾病、认知疾病和骨质疏松症。优化老年人的维生素B状态可能对预防退行性疾病有益。在此，我们广泛讨论维生素B在衰老过程中的作用。