Butt N, Chlad P, Bläser A, Pulzer F, Thome U H, Ackermann B W
Department of Neonatology, Leipzig University, Leipzig, Germany.
Department of Ophthalmology, Leipzig University, Leipzig, Germany.
Ophthalmic Epidemiol. 2025 Aug;32(4):455-463. doi: 10.1080/09286586.2024.2399346. Epub 2024 Dec 18.
To assess the efficacy of the DIGIROP-Birth algorithm in identifying infants at risk for developing retinopathy of prematurity (ROP).
In a retrospective study, we included preterm infants over 11 years, 2010-2020, meeting the inclusion criteria for the DIGIROP-Birth calculator (24 + 0/7 to 30 + 6/7 weeks of gestational age). We assessed the validity of DIGIROP-Birth using receiver-operating characteristic (ROC) curves and calculated area-under-curve (AUC), sensitivity, specificity, and positive and negative predictive values.
897 infants were included in the analysis. The median age of the first ophthalmological examination was 40 days (IQR 32-50), the median gestational age was 198 days (IQR 185-209; corresponding to 28 + 2/7 gestational weeks), median birth weight was 1000 g (IQR 790-1300). Of 897 screened children, 458 (51.1%) were diagnosed with ROP, and 34 of 897 (3.8%) required treatment.Analysis of ROP requiring treatment predicted by DIGIROP showed an AUC of 0.860 [95%-CI 0.795-0.925]. An equilibrium of sensitivity and specificity existed at a probability of 4.12%. The positive predictive value was 10.95%, and the negative predictive value was 99.36%. Independent significant peri- and postnatal risk factors were emergency cesarean section and mass blood transfusions.
The DIGIROP-Birth calculator showed good predictive power in our studied population, with an incidence of 3.79% for therapy-requiring ROP. Peri- and postnatal risk factors should be included in ROP screening.
评估DIGIROP-Birth算法在识别有发生早产儿视网膜病变（ROP）风险的婴儿方面的有效性。
在一项回顾性研究中，我们纳入了2010年至2020年期间超过11岁的早产儿，这些早产儿符合DIGIROP-Birth计算器的纳入标准（胎龄24+0/7至30+6/7周）。我们使用受试者操作特征（ROC）曲线评估DIGIROP-Birth的有效性，并计算曲线下面积（AUC）、敏感性、特异性以及阳性和阴性预测值。
897名婴儿纳入分析。首次眼科检查的中位年龄为40天（四分位间距32-50），中位胎龄为198天（四分位间距185-209；相当于28+2/7孕周），中位出生体重为1000克（四分位间距790-1300）。在897名筛查儿童中，458名（51.1%）被诊断为ROP，897名中有34名（3.8%）需要治疗。对DIGIROP预测的需要治疗的ROP分析显示AUC为0.860[95%置信区间0.795-0.925]。在概率为4.12%时存在敏感性和特异性的平衡。阳性预测值为10.95%，阴性预测值为99.36%。独立的围产期和产后显著风险因素是急诊剖宫产和大量输血。
DIGIROP-Birth计算器在我们的研究人群中显示出良好的预测能力，需要治疗的ROP发生率为3.79%。围产期和产后风险因素应纳入ROP筛查。
