Liu Jialin, Li Ruizhen, Qin Lei, Fu Dongju, Wang Moeiling, Liu Weifeng, Liu Xuguang
Institute of New Carbon Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Key Laboratory of Interface Science and Engineering in Advanced Materials (Taiyuan University of Technology), Ministry of Education, Taiyuan 030024, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Mar 15;329:125590. doi: 10.1016/j.saa.2024.125590. Epub 2024 Dec 14.
Propranolol, a medication used to treat cardiovascular diseases, can be harmful when overdosed and hazardous to ecosystems if released into the environment. Here, a new molecularly imprinted fluorescent sensor was developed from carbon dots through a sol-gel method. Carbon dots served as both the fluorescent signal and the carrier, with propranolol as the template molecule and 3-aminopropyltriethoxysilane as the functional monomer to be grafted on carbon dots' surface. A novel detection method was established for the efficient, rapid, and cost-effective detection of propranolol in human plasma through quantitative analysis by using a fluorescence spectrophotometer and an ultraviolet spectrophotometer. Under the optimal conditions, the detection range of 0.5-4 mg L, the detection limit of 0.092 mg L, the imprinting factor of 2.42, and the detection response time of 2 min were achieved. The prepared carbon dot-based molecularly imprinted fluorescent sensor was proved to have a wide accurate linear range, low detection limit, and very short response time, and can detect lower analyte concentrations with higher detection accuracy.
普萘洛尔是一种用于治疗心血管疾病的药物，过量服用时可能有害，如果释放到环境中则会对生态系统造成危害。在此，通过溶胶-凝胶法从碳点开发了一种新型分子印迹荧光传感器。碳点既是荧光信号又是载体，以普萘洛尔为模板分子，3-氨丙基三乙氧基硅烷为功能单体接枝在碳点表面。通过使用荧光分光光度计和紫外分光光度计进行定量分析，建立了一种高效、快速且经济高效的检测人血浆中普萘洛尔的新方法。在最佳条件下，实现了0.5-4mg/L的检测范围、0.092mg/L的检测限、2.42的印迹因子和2分钟的检测响应时间。所制备的基于碳点的分子印迹荧光传感器被证明具有宽的准确线性范围、低检测限和非常短的响应时间，并且能够以更高的检测准确度检测更低的分析物浓度。
