Hoover-Plow J L, Sinha Y N
Proc Soc Exp Biol Med. 1985 Feb;178(2):234-9. doi: 10.3181/00379727-178-42004.
Weanling male rats were trained to consume a control diet in one 4-hr meal a day. Rats were then fed one of three experimental diets for 7 days: (a) control diet minus B6 (-B6); (b) control diet (B6); or (c) control diet restricted to food intake of -B6 (B6R). Xanthurenic acid excretion was greater before and after a tryptophan load in -B6 than in B6R. Body weight gain, food intake, and food efficiency were not different between -B6 and B6. However, in B6R body weight gain, food intake and food efficiency were lower than that in both -B6 and B6. Serum glucose (12-16 hr after meal) and percentage body fat were similar in all three groups. No differences were found in organ size between the -B6 and both control groups indicating that short-term deprivation and deoxypyridoxine did not affect organ size. No significant differences were observed for serum growth hormone (GH), pituitary GH, serum prolactin (PRL), or pituitary PRL among the three groups. When meal fed, differences were minimized between B6 deprived and unrestricted control (B6) rats in body weight gain, food intake, food efficiency, and body composition.
将断乳雄性大鼠训练为每天在一餐中摄取对照饮食，每餐4小时。然后给大鼠喂食三种实验饮食之一，持续7天：(a) 不含维生素B6的对照饮食（-B6）；(b) 对照饮食（B6）；或(c) 限制食物摄入量至-B6水平的对照饮食（B6R）。与B6R组相比，-B6组在色氨酸负荷前后的黄尿酸排泄量更高。-B6组和B6组之间的体重增加、食物摄入量和食物效率没有差异。然而，B6R组的体重增加、食物摄入量和食物效率低于-B6组和B6组。三组的血清葡萄糖（餐后12 - 16小时）和体脂百分比相似。-B6组与两个对照组之间的器官大小没有差异，表明短期剥夺和脱氧吡哆醇不影响器官大小。三组之间的血清生长激素（GH）、垂体GH、血清催乳素（PRL）或垂体PRL没有显著差异。当以餐饲方式喂养时，维生素B6缺乏的大鼠与不受限制的对照（B6）大鼠在体重增加、食物摄入量、食物效率和身体组成方面的差异最小化。
