Melius P, Svacha A J
J Nutr Sci Vitaminol (Tokyo). 1980;26(4):349-56. doi: 10.3177/jnsv.26.349.
The effects of three vitamin B6 analogs were studied in young adult and weanling rats. The 2-ethyl analog was the most active. It produced higher growth rates, an average feed efficiency equal to the control and elevated liver glycogen levels. Xanthurenic acid excretion remained low with the 2-ethyl analog and pyridoxine in the diet and plasma amino acid concentration was low. Response to the 2-n-propyl analog was similar to that of a B6-deficient diet, with a large increase in xanthurenic acid excretion. Rats receiving the 2-isopropyl analog were intermediate between the ethyl group and B6-deficient animals in all parameters measured. These in vivo results parallel those reported in the in vitro yeast pyridoxine dehydrogenase enzyme system. The ethyl pyridoxine analog was the most active of all the analogs in the yeast dehydrogenase system, in supporting growth and in maintaining normal xanthurenic acid excretion in the rat.
研究了三种维生素B6类似物对成年和断奶幼鼠的影响。2-乙基类似物活性最强。它能提高生长速率，平均饲料效率与对照组相当，并提高肝脏糖原水平。饮食中添加2-乙基类似物和吡哆醇时，黄尿酸排泄量仍然较低，血浆氨基酸浓度也较低。对2-正丙基类似物的反应与缺乏维生素B6的饮食相似，黄尿酸排泄量大幅增加。在所有测量参数方面，接受2-异丙基类似物的大鼠介于乙基组和缺乏维生素B6的动物之间。这些体内实验结果与体外酵母吡哆醇脱氢酶系统中报道的结果一致。在酵母脱氢酶系统中，乙基吡哆醇类似物在支持大鼠生长和维持正常黄尿酸排泄方面是所有类似物中活性最强的。
