Brown Taylor, Kanel Prabesh, Griggs Alexis, Carli Giulia, Vangel Robert, Albin Roger L, Bohnen Nicolaas I
Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Functional Neuroimaging, Cognitive, and Mobility Laboratory, University of Michigan, Ann Arbor, MI, USA.
Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Morris K. Udall Center of Excellence for Parkinson's Disease Research, University of Michigan, Ann Arbor, MI, USA; Parkinson's Foundation Research Center of Excellence, University of Michigan, Ann Arbor, MI, USA; Functional Neuroimaging, Cognitive, and Mobility Laboratory, University of Michigan, Ann Arbor, MI, USA.
Parkinsonism Relat Disord. 2025 Feb;131:107229. doi: 10.1016/j.parkreldis.2024.107229. Epub 2024 Dec 9.
Visual and visual processing deficits are implicated in freezing, falling, and cognitive impairments in Parkinson's disease (PD). In particular, contrast sensitivity deficits are common and may be related to cognitive impairment in PD. While dopaminergic deficits play a role in PD-related visual dysfunction, brain cholinergic systems also modulate many aspects of visual processing. The aim of this study was to explore regional cerebral cholinergic terminal density correlates of contrast sensitivity in PD. Ninety-one PD subjects underwent contrast sensitivity testing, motor testing, cognitive testing, and brain MRI and [F]-fluoroethoxybenzovesamicol [F]-FEOBV PET imaging. Whole brain false discovery error-corrected (p < 0.05) correlations revealed significant associations between VAChT deficits in pericentral, limbic, and visual processing regions and contrast sensitivity performance, independent of disease duration and dopaminergic medication doses. These results suggest that brain cholinergic deficits correlate with contrast sensitivity deficits in PD. Additionally, decreased Rabin contrast sensitivity scores were associated with lower total scores in the Parkinson's Disease Cognitive Rating Scale. These findings suggest that diminished cognitive performance correlated with contrast sensitivity partly reflects underlying vulnerabilities of brain cholinergic systems.
视觉及视觉处理缺陷与帕金森病（PD）中的冻结现象、跌倒及认知障碍有关。尤其是，对比敏感度缺陷很常见，且可能与PD中的认知障碍有关。虽然多巴胺能缺陷在与PD相关的视觉功能障碍中起作用，但脑胆碱能系统也调节视觉处理的许多方面。本研究的目的是探讨PD中对比敏感度与区域脑胆碱能终末密度的相关性。91名PD患者接受了对比敏感度测试、运动测试、认知测试、脑部MRI及[F] - 氟乙氧基苯甲酰甲基碘化铵[F] - FEOBV PET成像。全脑错误发现率校正（p < 0.05）的相关性显示，中央周围、边缘及视觉处理区域的囊泡乙酰胆碱转运体（VAChT）缺陷与对比敏感度表现之间存在显著关联，且不受病程及多巴胺能药物剂量的影响。这些结果表明，脑胆碱能缺陷与PD中的对比敏感度缺陷相关。此外，帕金森病认知评定量表中较低的总得分与降低的Rabin对比敏感度评分相关。这些发现表明，与对比敏感度相关的认知表现下降部分反映了脑胆碱能系统的潜在脆弱性。
