Kaya Huseyin, Boyaci Hasim, Argun Baris Serap, Basyigit Ilknur, Ozsoy Ozgur Doga, Maral Kir Hale
Chest Diseases, Kocaeli City Hospital, Kocaeli, Turkey.
Chest Diseases, University of Kocaeli, Kocaeli, Turkey.
BMC Pulm Med. 2024 Dec 18;24(1):623. doi: 10.1186/s12890-024-03412-z.
Sarcoidosis is a chronic disease of unknown etiology characterised by systemic non-caseating granulomas that can affect any organ in the body, especially the lungs and in which genetic and environmental factors are thought to play a role in its pathophysiology. Adipokines and myokines secreted from adipose and muscle tissue play a role in the pathogenesis or protection against many inflammatory and autoimmune diseases in which inflammation and immunity form the basis. In our study, we aimed to investigate the role of the irisin and adiponectin in sarcoidosis.
The study included 90 sarcoidosis patients and 86 healthy subjects. Adiponectin and irisin levels were analysed in addition to standard tests for diagnosis and follow-up of patients with sarcoidosis. The sensitivity and specificity of serum irisin levels for the diagnosis of sarcoidosis were evaluate dusing ROC analysis.
Irisin levels were significantly lower in the patient group than in the control group (3.28-5.25, p < 0.001). There was no association between irisin levels and extrapulmonary involvement. The cut-off irisin value for the diagnosis of sarcoidosis was ≤ 4.2662 with 95% confidence interval, and the sensitivity and specificity were calculated as 84% and 55.8%, respectively.
To our knowledge, this is the first study to investigate irisin in sarcoidosis patients. Based on the available evidence, anti-inflammatory, anti-oxidant and anti-apoptocic effects of irisin may play a role in the pathophysiology of sarcoidosis. Although no significant difference was found in our study, we believe that a comprehensive evaluation of adiponectin in sarcoidosis is important.
结节病是一种病因不明的慢性疾病，其特征为系统性非干酪样肉芽肿，可累及身体的任何器官，尤其是肺部，人们认为遗传和环境因素在其病理生理学中发挥作用。脂肪组织和肌肉组织分泌的脂肪因子和肌动蛋白在许多以炎症和免疫为基础的炎症性和自身免疫性疾病的发病机制或预防中发挥作用。在我们的研究中，我们旨在探讨鸢尾素和脂联素在结节病中的作用。
该研究纳入了90例结节病患者和86名健康受试者。除了对结节病患者进行诊断和随访的标准检查外，还分析了脂联素和鸢尾素水平。使用ROC分析评估血清鸢尾素水平对结节病诊断的敏感性和特异性。
患者组的鸢尾素水平显著低于对照组（3.28 - 5.25，p < 0.001）。鸢尾素水平与肺外受累之间无关联。结节病诊断的鸢尾素临界值≤4.2662，95%置信区间，敏感性和特异性分别计算为84%和55.8%。
据我们所知，这是第一项研究结节病患者鸢尾素的研究。基于现有证据，鸢尾素的抗炎、抗氧化和抗凋亡作用可能在结节病的病理生理学中发挥作用。尽管在我们的研究中未发现显著差异，但我们认为对结节病中脂联素进行全面评估很重要。
