结节病患者的血清脂肪因子水平。

Serum adipokine levels in patients with sarcoidosis.

机构信息

Faculty of Medicine, Department of Internal Medicine and Rheumatology, WASOG Sarcoidosis Clinic, Istinye University, Istanbul, Turkey.

Department of Internal Medicine, Faculty of Medicine, Ege University, İzmir, Turkey.

出版信息

Clin Rheumatol. 2020 Jul;39(7):2121-2125. doi: 10.1007/s10067-020-04980-1. Epub 2020 Feb 14.

DOI:10.1007/s10067-020-04980-1

PMID:32060810

Abstract

BACKGROUND

Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role in the pathogenesis of sarcoidosis.

OBJECTIVES

To evaluate the serum adipokine levels in patients with sarcoidosis and to determine a possible correlation with clinical and laboratory signs of disease.

METHODS

Forty-four biopsy-proven sarcoidosis patients followed at a single center and age- and sex-matched 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data were recorded and body mass index (BMI) was calculated in all patients. Routine laboratory tests (blood glucose, liver, and kidney function test) were measured. Serum adiponectin and leptin levels were measured by ELISA method.

RESULTS

Among 44sarcoidosis patients, 13 (29.5%) were male and 31 (70.5%) were female. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40 (90.9%) had arthralgia, 32 (72.7%) had arthritis, 15 (34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE level in 24 (54.5%) patients, increased serum calcium level in 11 (25%) patients, increased serum D3 level in 5 (11.4%) patients, and increased ESR and CRP levels in 22 (50%) and 23 (52.3%) patients, respectively. Compared with the control group, serum adiponectin levels were significantly higher in patients with sarcoidosis(p = 0.007). Serum adiponectin level was associated with arthralgia and ankle joint swelling (p = 0.007, p = 0.006 respectively). Serum leptin levels were similar in sarcoidosis patients and controls (p = 0.327). There was no relationship between serum leptin level and disease features (p > 0.05).

CONCLUSIONS

In this study, high serum adiponectin level was detected in patients with sarcoidosis while serum leptin level was similar in the sarcoidosis and control group. Adiponectin, an anti-inflammatory protein, may play a role in the pathogenesis of sarcoidosis. Studies are needed to shed light on this topic.Key Points• Sarcoidosis is a chronic granulomatous disease characterized by granuloma formation• High serum adiponectin level was found in sarcoidosis patients• Serum adiponectin level was associated with some clinical features such as arthralgia and arthritis• High adiponectin levels in sarcoidosis patients may mitigate the inflammatory response, resulting in a mild form of the disease and/or spontaneous remission.

摘要

背景

结节病是一种慢性炎症性疾病，其特征是非干酪样肉芽肿，病因不明。脂肪细胞因子是由脂肪组织合成的不同蛋白质，对血管生成、止血、脂质代谢和免疫系统调节有影响。脂肪细胞因子可能在结节病的发病机制中起作用。

目的

评估结节病患者的血清脂肪细胞因子水平，并确定其与疾病的临床和实验室征象之间的可能相关性。

方法

纳入在单一中心接受治疗的 44 例活检证实的结节病患者，并与 41 名年龄和性别匹配的健康志愿者进行了比较。记录所有患者的人口统计学、临床、实验室和影像学数据，并计算体重指数（BMI）。进行常规实验室检查（血糖、肝肾功能检查）。采用 ELISA 法测定血清脂联素和瘦素水平。

结果

44 例结节病患者中，13 例（29.5%）为男性，31 例（70.5%）为女性。21 例（47.7%）患者有结节性红斑，3 例（6.8%）有葡萄膜炎，40 例（90.9%）有关节痛，32 例（72.7%）有关节炎，15 例（34.1%）有肌腱炎。实验室评估显示，24 例（54.5%）患者血清 ACE 水平升高，11 例（25%）患者血清钙水平升高，5 例（11.4%）患者血清 D3 水平升高，22 例（50%）和 23 例（52.3%）患者的 ESR 和 CRP 水平分别升高。与对照组相比，结节病患者的血清脂联素水平显著升高（p=0.007）。血清脂联素水平与关节痛和踝关节肿胀相关（p=0.007，p=0.006）。结节病患者和对照组的血清瘦素水平相似（p=0.327）。血清瘦素水平与疾病特征之间无相关性（p＞0.05）。