Bruno Tiziana, Catena Valeria, Blandino Giovanni, Fanciulli Maurizio, Di Agostino Silvia
SAFU Laboratory, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
J Exp Clin Cancer Res. 2024 Dec 18;43(1):322. doi: 10.1186/s13046-024-03248-9.
Multiple myeloma (MM), a hematologic malignancy characterized by the clonal expansion of plasma cells within the bone marrow, is associated with severe health complications, including osteolytic bone lesions that significantly increase the risk of fractures, leading to higher morbidity and mortality rates. One intriguing protein in this context is the RNA polymerase binding factor Che-1/AATF (Che-1), which has emerged as a potential player in the survival and proliferation of myeloma cells. Hippo pathway has been shown to be an important mediator of oncogenesis in solid tumors, especially for its role in shaping a tumor microenvironment favorable to cancer maintenance and spread. The Hippo pathway is also implicated in the pathogenesis of the osteolytic lesions that occurs in MM, since it deregulates the activities of mesenchymal populations of the bone matrix. In this commentary we wish to highlight some new molecular aspects elucidated in the paper by Bruno et al. regarding the proliferation of MM and the onset of bone lesions [Leukemia 38:877-882, 1]. A series of recent findings has revealed a crosstalk between the RNA polymerase binding factor Che-1 and the HIPPO downstream co-transcriptional factor TAZ, bringing to light new emerging molecular targets in MM to limit the development of bone lesions.
多发性骨髓瘤（MM）是一种血液系统恶性肿瘤，其特征是骨髓内浆细胞的克隆性扩增，与严重的健康并发症相关，包括溶骨性骨病变，这显著增加了骨折风险，导致更高的发病率和死亡率。在这种情况下，一种有趣的蛋白质是RNA聚合酶结合因子Che-1/AATF（Che-1），它已成为骨髓瘤细胞存活和增殖的潜在参与者。Hippo通路已被证明是实体瘤肿瘤发生的重要介质，特别是因其在塑造有利于癌症维持和扩散的肿瘤微环境中的作用。Hippo通路也与MM中发生的溶骨性病变的发病机制有关，因为它会失调骨基质间充质群体的活性。在这篇评论中，我们希望强调Bruno等人的论文中阐明的关于MM增殖和骨病变发生的一些新的分子方面[《白血病》38:877 - 882，1]。一系列最新发现揭示了RNA聚合酶结合因子Che-1与HIPPO下游共转录因子TAZ之间的相互作用，揭示了MM中限制骨病变发展的新出现的分子靶点。
