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Che-1/miR-590-3p/TAZ axis sustains multiple myeloma disease.

作者信息

Bruno Tiziana, Catena Valeria, Corleone Giacomo, Cortile Clelia, Cappelletto Maria Chiara, Bellei Barbara, De Nicola Francesca, Amadio Bruno, Gumenyuk Svitlana, Marchesi Francesco, Annibali Ombretta, Blandino Giovanni, Fanciulli Maurizio, Di Agostino Silvia

机构信息

SAFU Laboratory, Department of Research, Advanced Diagnostics, and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Microbiology and Virology Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

出版信息

Leukemia. 2024 Apr;38(4):877-882. doi: 10.1038/s41375-024-02168-z. Epub 2024 Feb 17.

DOI:10.1038/s41375-024-02168-z
PMID:38368441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10997508/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/10997508/750d387f19a3/41375_2024_2168_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/10997508/accf0cf4d15e/41375_2024_2168_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/10997508/750d387f19a3/41375_2024_2168_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/10997508/accf0cf4d15e/41375_2024_2168_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f17b/10997508/750d387f19a3/41375_2024_2168_Fig2_HTML.jpg

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本文引用的文献

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AATF/Che-1 localizes to paraspeckles and suppresses R-loops accumulation and interferon activation in Multiple Myeloma.AATF/Che-1 定位于核周斑点，并抑制多发性骨髓瘤中 R 环的积累和干扰素的激活。
EMBO J. 2022 Nov 17;41(22):e109711. doi: 10.15252/embj.2021109711. Epub 2022 Aug 5.
2
Regulation of Hippo signaling pathway in cancer: A MicroRNA perspective.Hippo 信号通路在癌症中的调控：miRNA 的视角
Cell Signal. 2021 Feb;78:109858. doi: 10.1016/j.cellsig.2020.109858. Epub 2020 Nov 27.
3
Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma.
分子见解揭示多发性骨髓瘤和骨病管理的治疗潜力。
J Exp Clin Cancer Res. 2024 Dec 18;43(1):322. doi: 10.1186/s13046-024-03248-9.
4
Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value.长链非编码RNA TPRG1-AS1在宫颈鳞状细胞癌发生发展中的作用及其预后价值
Discov Oncol. 2024 Dec 18;15(1):754. doi: 10.1007/s12672-024-01654-1.
Che-1/AATF 诱导的转录活性染色质促进多发性骨髓瘤细胞增殖。
Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566.
4
TAZ functions as a tumor suppressor in multiple myeloma by downregulating MYC.TAZ 通过下调 MYC 发挥抑癌作用，抑制多发性骨髓瘤的生长。
Blood Adv. 2019 Nov 26;3(22):3613-3625. doi: 10.1182/bloodadvances.2019000374.
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Emerging Insights Into the Role of the Hippo Pathway in Multiple Myeloma and Associated Bone Disease.Hippo 通路在多发性骨髓瘤及相关骨病中的作用的新见解。
Clin Lymphoma Myeloma Leuk. 2020 Feb;20(2):57-62. doi: 10.1016/j.clml.2019.09.620. Epub 2019 Oct 9.
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Pathogenesis of bone disease in multiple myeloma: from bench to bedside.多发性骨髓瘤中骨病的发病机制：从基础到临床。
Blood Cancer J. 2018 Jan 12;8(1):7. doi: 10.1038/s41408-017-0037-4.
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Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma.胸苷磷酸化酶对骨髓瘤中的骨吸收和骨形成具有复杂的影响。
Sci Transl Med. 2016 Aug 24;8(353):353ra113. doi: 10.1126/scitranslmed.aad8949.
8
Discovering Che-1/AATF: a new attractive target for cancer therapy.发现Che-1/AATF：癌症治疗的一个新的有吸引力的靶点。
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EMBO J. 2015 May 5;34(9):1214-30. doi: 10.15252/embj.201489920. Epub 2015 Mar 14.
10
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.Hippo 通路效应物 TAZ 和 YAP 在发育、稳态和疾病中的作用。
Development. 2014 Apr;141(8):1614-26. doi: 10.1242/dev.102376.