Zhao Ying, Qiu Wenqiang, Weng Xiangtao, Gu Chiming, Li Siyi
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Traditional Chinese Medicine), Guangzhou, China.
Diagn Pathol. 2024 Dec 18;19(1):157. doi: 10.1186/s13000-024-01585-z.
We reported a case of anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK + ALCL) involving the bladder. The patient was a 27-year-old female, whose main clinical symptoms included fever, painless lymphadenopathy, and hematuria. Imaging studies suggested a bladder mass. The bladder mass was maximally resected through transurethral bladder tumor resection. The pathology report indicated a malignant tumor of the bladder. Based on immunohistochemical and gene rearrangement results, the diagnosis was confirmed as ALK + ALCL. After undergoing five cycles of treatment with the BV + CHP chemotherapy regimen, the patient's condition is currently stable, and no tumor recurrence was observed upon re-examination. ALK + ALCL involving the bladder is very rare, and early diagnosis is challenging. By reviewing the diagnostic and treatment process of this patient, and in conjunction with a review of modern literature on the disease's incidence characteristics, treatment protocols, and prognosis, this aims to provide a reference for clinicians in diagnosing and treating this condition, thereby reducing delays.
我们报告了一例累及膀胱的间变性淋巴瘤激酶（ALK）阳性间变性大细胞淋巴瘤（ALK+ALCL）病例。患者为一名27岁女性，其主要临床症状包括发热、无痛性淋巴结病和血尿。影像学检查提示膀胱有肿块。通过经尿道膀胱肿瘤切除术对膀胱肿块进行了最大限度的切除。病理报告显示为膀胱恶性肿瘤。根据免疫组织化学和基因重排结果，确诊为ALK+ALCL。在接受了五个周期的BV+CHP化疗方案治疗后，患者目前病情稳定，复查未观察到肿瘤复发。累及膀胱的ALK+ALCL非常罕见，早期诊断具有挑战性。通过回顾该患者的诊断和治疗过程，并结合对有关该疾病发病率特征、治疗方案和预后的现代文献的综述，旨在为临床医生诊断和治疗这种疾病提供参考，从而减少延误。
