Liu Wenjin, Jin You, Wu Yongyan, Xiao Zhenni, Xu Yan, Du Zhaohong, Xiao Jianmei, Yan Zhipeng
Outpatient Department, Guangzhou University, Guangzhou, 510006, China.
BMC Infect Dis. 2024 Dec 18;24(1):1443. doi: 10.1186/s12879-024-10346-8.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause repeated infections. China experienced an outbreak of COVID-19 (coronavirus disease 2019) after the Chinese government changed its COVID-19 policy in December 2022. However, little is known about the influencing factors, such as a history of previous infection and vaccine dose, and whether these factors affect the time at which the antigen test results become negative for SARS-CoV-2. Boarding colleges and universities are prone to outbreaks caused by COVID-19. Therefore, we investigated the factors influencing the time of COVID-19 antigen tests conversion at one university from April to June 2023.
This study included college students from one university in Guangzhou who tested positive for the COVID-19 antigen and collected information such as sex, history of previous COVID-19 infection, vaccination dose, symptom onset date, and antigen tests conversion date for retrospective analysis. Chi-square tests or t-tests were used to compare differences between groups.
A total of 255 college students were included in this study. In addition to fever, the most common symptoms were sore throat, nasal symptoms and fatigue. The average time to antigen tests negative conversion of patients with their first infection was 6.12 ± 1.83 days, and that of patients with their second infection was 4.70 ± 1.43 days. The difference between the groups was statistically significant (P < 0.001). The average time to antigen tests negative conversion was 6.21 ± 1.92 days in patients with more than 3 symptoms except fever, which was significantly greater than that in patients with 0-1 (5.54 ± 1.79 days) or 2-3 symptoms (5.45 ± 1.78 days) (P < 0.05). There was no significant difference in time to antigen tests negative conversion according to sex, health observation location or vaccination dose (P > 0.05).
In college students, a history of SARS-CoV-2 infection as well as the number of symptoms were significantly associated with the time to COVID-19 antigen tests conversion.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）可导致反复感染。2022年12月中国政府调整新冠疫情防控政策后，中国经历了新冠病毒病（COVID-19）疫情暴发。然而，对于既往感染史和疫苗接种剂量等影响因素，以及这些因素是否会影响SARS-CoV-2抗原检测结果转为阴性的时间，人们知之甚少。寄宿制高校容易发生由COVID-19引起的疫情暴发。因此，我们调查了2023年4月至6月期间某所大学影响COVID-19抗原检测转阴时间的因素。
本研究纳入了广州某大学COVID-19抗原检测呈阳性的大学生，并收集了性别、既往COVID-19感染史、疫苗接种剂量、症状出现日期和抗原检测转阴日期等信息进行回顾性分析。采用卡方检验或t检验比较组间差异。
本研究共纳入255名大学生。除发热外，最常见的症状是咽痛、鼻部症状和乏力。首次感染患者抗原检测转阴的平均时间为6.12±1.83天，第二次感染患者为4.70±1.43天。两组之间的差异具有统计学意义（P<0.001）。除发热外有3种以上症状的患者抗原检测转阴的平均时间为6.21±1.92天，显著长于有0-1种症状（5.54±1.79天）或2-3种症状（5.45±1.78天）的患者（P<0.05）。根据性别、健康观察地点或疫苗接种剂量，抗原检测转阴时间无显著差异（P>0.05）。
在大学生中，SARS-CoV-2感染史以及症状数量与COVID-19抗原检测转阴时间显著相关。
