Hidaka Yosuke, Hashimoto Mamoru, Suehiro Takashi, Fukuhara Ryuji, Ishikawa Tomohisa, Tsunoda Naoko, Koyama Asuka, Honda Kazuki, Miyagawa Yusuke, Yoshiura Kazuhiro, Yuuki Seiji, Kajitani Naoto, Boku Shuken, Ishii Kazunari, Ikeda Manabu, Takebayashi Minoru
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Neuropsychiatry, Faculty of Medicine, Kindai University, Osaka, Japan.
Fluids Barriers CNS. 2024 Dec 18;21(1):101. doi: 10.1186/s12987-024-00601-0.
An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults.
We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia.
In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume.
CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required.
脉络丛（CP）体积增加可能与无痴呆的老年人认知功能下降有关。在本研究中，我们旨在阐明CP体积是否可作为认知功能下降的影像学标志物，确定CP体积与认知功能下降的关联强度，并探讨与老年人CP体积相关的因素。
我们测量了社区居住的年龄≥65岁且无痴呆的老年人的CP体积、脑实质以及与蛛网膜下腔不成比例扩大性脑积水（DESH，正常压力脑积水的一种影像学特征）相关的脑脊液（CSF）间隙。
在1370名参与者中，即使在调整了与DESH相关的CSF间隙和脑实质体积后，较低的简易精神状态检查表（MMSE）评分仍与较高的CP体积显著相关。与与DESH相关的CSF间隙和脑实质体积相比，CP体积与MMSE评分的关联更强。吸烟史、白质高信号、血管周围间隙扩大、年龄、体重指数和糖尿病也与CP体积增加有关。
CP体积可能是社区居住的无痴呆老年人认知功能下降的高度敏感影像学标志物，因为它与认知功能下降的关联独立于脑实质和CSF体积。我们的研究结果强调了研究CP体积增加对维持老年人认知功能的重要性。因此，需要进一步的纵向研究。
