Xie Qianqian, Chen Ziwei, Wang Jiafeng, Zhang Huisi, Wang Yan, Wang Xiaoyu, Li Chunyan, Wang Yongxiang, Cong Lin, Ferreira Daniel, Welmer Anna-Karin, Song Lin, Du Yifeng, Qiu Chengxuan
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China.
Fluids Barriers CNS. 2025 Apr 3;22(1):33. doi: 10.1186/s12987-025-00642-z.
The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies have thus far examined the association of ChP with physical function in older people.
This population-based cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. ChP volume was automatically segmented using three-dimensional T1-weighted sequences. Physical function was assessed using the Short Physical Performance Battery (SPPB). Data were analyzed using general linear regression and mediation models.
Controlling for demographic characteristics, cardiovascular risk factors, stroke, disproportionately enlarged subarachnoid-space hydrocephalus (DESH), and total intracranial volume, per 1-ml increase in ChP volume was associated with β-coefficient of -0.24 (95% confidence interval: -0.37 to -0.11) for SPPB summary score, with the association being stronger in females (-0.40; -0.60 to -0.20) than in males (-0.17; -0.33 to -0.01) (p for ChP volume×sex interaction = 0.028). The associations were similar across three domains of balance, chair stand, and walking speed. In addition, enlarged ChP volume was associated with increased ventricular volume and white matter hyperintensity (WMH) volume. Mediation analysis suggested that lateral ventricular volume and periventricular WMH volume significantly mediated the association of ChP volume with the SPPB summary score, with the proportion of mediation being 54.22% and 14.48%, respectively.
Larger ChP volume is associated with poorer physical function in older adults, especially in women. The association is largely mediated by lateral ventricular and periventricular WMH volumes.
脉络丛在脑脊液生成中起重要作用，身体功能障碍与脑脊液循环改变有关。然而，迄今为止尚无基于人群的研究探讨老年人脉络丛与身体功能之间的关联。
这项基于人群的横断面研究纳入了中国农村延缓痴呆和残疾多模式干预MRI子研究中的1217名参与者（年龄≥60岁；女性占57.35%）。使用三维T1加权序列自动分割脉络丛体积。使用简短体能状况量表（SPPB）评估身体功能。采用一般线性回归和中介模型分析数据。
在控制人口统计学特征、心血管危险因素、中风、蛛网膜下腔不成比例扩大性脑积水（DESH）和总颅内体积后，脉络丛体积每增加1ml，SPPB总分的β系数为-0.24（95%置信区间：-0.37至-0.11），女性（-0.40；-0.60至-0.20）的关联比男性（-0.17；-0.33至-0.01）更强（脉络丛体积×性别交互作用的p值=0.028）。在平衡、从椅子上站起和步行速度三个领域中，这种关联相似。此外，脉络丛体积增大与脑室体积增加和白质高信号（WMH）体积增加有关。中介分析表明，侧脑室体积和脑室周围WMH体积显著介导了脉络丛体积与SPPB总分之间的关联，中介比例分别为54.22%和14.48%。
脉络丛体积较大与老年人身体功能较差有关，尤其是女性。这种关联在很大程度上由侧脑室和脑室周围WMH体积介导。
