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实体器官移植患者的疫苗接种:建议、疗效与安全性

Vaccination for solid organ transplanted patients: Recommendations, efficacy, and safety.

作者信息

Velikova Tsvetelina, Gerasoudis Stavros, Batselova Hristiana

机构信息

Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria.

Faculty of Medicine, Trakia University, Stara Zagora 6000, Bulgaria.

出版信息

World J Transplant. 2024 Dec 18;14(4):92172. doi: 10.5500/wjt.v14.i4.92172.

Abstract

Solid organ transplant recipients face unique challenges in managing their immunosuppressed status, making vaccination a critical consideration. This review aimed to comprehensively analyze current recommendations, evaluate the efficacy of vaccinations in this population, and assess safety concerns. We explored the latest evidence on vaccine types, timing, and potential benefits for transplant patients, highlighting the importance of individualized approaches for routinely used vaccines as well as coronavirus disease 2019 vaccines. By synthesizing available data, this review underscored the pressing need to optimize vaccination strategies, ensuring that transplant recipients can obtain the full protection against many pathogens while minimizing risks associated with their post-transplant immunosuppression.

摘要

实体器官移植受者在管理自身免疫抑制状态上面临独特挑战,这使得疫苗接种成为一个关键考量因素。本综述旨在全面分析当前建议,评估该人群疫苗接种的效果,并评估安全性问题。我们探讨了关于疫苗类型、接种时间以及对移植患者潜在益处的最新证据,强调了针对常规使用疫苗以及2019冠状病毒病疫苗采取个体化方法的重要性。通过综合现有数据,本综述强调了优化疫苗接种策略的迫切需求,确保移植受者能够获得针对多种病原体的全面保护,同时将移植后免疫抑制相关风险降至最低。

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Vaccination in patients with kidney failure: lessons from COVID-19.肾衰竭患者的疫苗接种:COVID-19 带来的启示。
Nat Rev Nephrol. 2022 Nov;18(11):708-723. doi: 10.1038/s41581-022-00617-5. Epub 2022 Aug 23.

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