Garg Neha, Mandloi Shreya, Queenan Natalia, Trivedi Jay, McCann Adam, Xu Vivian, Amin Dev, Krein Howard, Heffelfinger Ryan
Department of Otolaryngology-Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia Pennsylvania USA.
Department of Otolaryngology-Head and Neck Surgery, Sidney Kimmel Medical College Thomas Jefferson University Philadelphia Pennsylvania USA.
OTO Open. 2024 Dec 18;8(4):e70054. doi: 10.1002/oto2.70054. eCollection 2024 Oct-Dec.
Mohs micrographic surgery (MMS) and subsequent reconstructive procedures for the treatment of facial nonmelanoma skin cancers (NMSCs) significantly impact quality of life (QoL). A validated patient-reported outcome measure (PROM) for patients who undergo Mohs reconstruction is not yet established. This study aims to systematically assess the quality of existing PROMs to determine their effectiveness in capturing the challenges faced after Mohs reconstruction for facial NMSC.
A systematic review following established Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines was performed. Medline, PubMed, Scopus, and Cochrane databases were searched using keywords relevant to MMS, NMSC, facial reconstruction, QoL, and PROMs.
Inclusion and exclusion criteria were used to compile eligible PROMs. Methodological quality and psychometric properties of PROMs were evaluated using COnsensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) criteria.
Of 2997 articles, 78 met the inclusion criteria. Of these, 45 studies utilized a PROM as an outcome measure, and 33 reported PROM development or validation. COSMIN assessment demonstrated that the FACE-Q Skin Cancer Module and Facial Skin Cancer Index have the strongest validation. The Mohs Reconstruction Questionnaire-12 (MRQ-12) was the only PROM specific to this population of interest; however, it has not undergone psychometric property assessment.
Various PROMs have been utilized to assess QoL for patients undergoing facial reconstructive surgery after MMS. A clinically validated PROM specific to this patient population is required to gain deeper insight into these emotional impacts. Further validation and psychometric testing of the MRQ-12 may be beneficial.
莫氏显微描记手术（MMS）及后续用于治疗面部非黑色素瘤皮肤癌（NMSC）的重建手术对生活质量（QoL）有显著影响。目前尚未建立针对接受莫氏重建手术患者的经过验证的患者报告结局指标（PROM）。本研究旨在系统评估现有PROM的质量，以确定其在捕捉面部NMSC莫氏重建术后所面临挑战方面的有效性。
按照既定的系统评价和Meta分析优先报告项目指南进行系统评价。使用与MMS、NMSC、面部重建、QoL和PROM相关的关键词检索了Medline、PubMed、Scopus和Cochrane数据库。
采用纳入和排除标准来汇总符合条件的PROM。使用基于共识的健康测量工具选择标准（COSMIN）标准评估PROM的方法学质量和心理测量特性。
在2997篇文章中，78篇符合纳入标准。其中，45项研究将PROM用作结局指标，33项报告了PROM的开发或验证情况。COSMIN评估表明，面部Q量表皮肤癌模块和面部皮肤癌指数的验证最为充分。莫氏重建问卷-12（MRQ-12）是唯一针对该目标人群的PROM；然而，它尚未进行心理测量特性评估。
已使用各种PROM来评估MMS后接受面部重建手术患者的QoL。需要一个针对该患者群体的经过临床验证的PROM，以更深入地了解这些情感影响。对MRQ-12进行进一步验证和心理测量测试可能会有所帮助。
