背根神经节刺激可改善克罗恩病所致使人衰弱的腹痛的功能：一项为期12个月的随访研究。
Dorsal root ganglion stimulation provides functional improvement from debilitating abdominal pain in Crohn's disease: A 12-month follow-up.
作者信息
Khawer Ahmed, Chopra Harman, AlFarra Tariq, Sivanesan Eellan
机构信息
Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Rehabilitation Medicine and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Interv Pain Med. 2024 Dec 2;3(4):100524. doi: 10.1016/j.inpm.2024.100524. eCollection 2024 Dec.
BACKGROUND
Crohn's disease (CD) is a chronic relapsing-remitting, immunological, inflammatory bowel disease involving any part of the gastrointestinal tract, most commonly, the terminal ileum. Abdominal pain is a prominent debilitating symptom of CD due to continuous intestinal inflammation, associated with disease severity and complications. However, abdominal pain has shown to occur even with disease remission.
CASE PRESENTATION
A female college student with a history of Crohn's Disease was referred for severe, chronic abdominal pain, with frequent flare-ups and hospitalizations. Due to her refractory debilitating pain, DRG stimulation was initiated with leads placed at right T11 and T12. Twelve months post-implantation, the patient reports 50-60 % reduction in pain, tolerance of an oral diet without postprandial pain, no occurrence of flares since implant, and an overall improvement in function and quality of life.
CONCLUSION
This report showcases the therapeutic potential of DRG stimulation in managing intractable chronic abdominal pain in inflammatory bowel diseases such as Crohn's disease.
背景
克罗恩病（CD）是一种慢性复发-缓解型免疫性炎症性肠病，可累及胃肠道的任何部位，最常见于回肠末端。由于肠道持续炎症，腹痛是CD的一个突出的使人衰弱的症状，与疾病严重程度和并发症相关。然而，即使在疾病缓解期也会出现腹痛。
病例报告
一名有克罗恩病病史的女大学生因严重的慢性腹痛前来就诊，腹痛频繁发作且多次住院。由于其顽固性衰弱性疼痛，在右侧T11和T12放置电极进行背根神经节（DRG）刺激。植入后12个月，患者报告疼痛减轻了50%-60%，能够耐受口服饮食且无餐后疼痛，自植入后未再发作，功能和生活质量总体得到改善。
结论
本报告展示了DRG刺激在治疗诸如克罗恩病等炎症性肠病中难治性慢性腹痛方面的治疗潜力。
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