Wils Pauline, Caron Bénédicte, D'Amico Ferdinando, Danese Silvio, Peyrin-Biroulet Laurent
Department of Gastroenterology, Claude Huriez Hospital, University of Lille, F-59000 Lille, France.
Department of Gastroenterology, University of Lorraine, CHRU-Nancy, F-54000 Nancy, France.
J Clin Med. 2022 Jul 22;11(15):4269. doi: 10.3390/jcm11154269.
Up to 60% of inflammatory bowel disease (IBD) patients experience abdominal pain in their lifetime regardless of disease activity. Pain negatively affects different areas of daily life and particularly impacts the quality of life of IBD patients. This review provides a comprehensive overview of the multifactorial etiology implicated in the chronic abdominal pain of IBD patients including peripheral sensitization by inflammation, coexistent irritable bowel syndrome, visceral hypersensitivity, alteration of the brain-gut axis, and the multiple factors contributing to pain persistence. Despite the optimal management of intestinal inflammation, chronic abdominal pain can persist, and pharmacological and non-pharmacological approaches are necessary. Integrating psychological support in care models in IBD could decrease disease burden and health care costs. Consequently, a multidisciplinary approach similar to that used for other chronic pain conditions should be recommended.
高达60%的炎症性肠病（IBD）患者在其一生中会经历腹痛，无论疾病活动状态如何。疼痛会对日常生活的不同方面产生负面影响，尤其会影响IBD患者的生活质量。本综述全面概述了IBD患者慢性腹痛的多因素病因，包括炎症引起的外周敏化、并存的肠易激综合征、内脏超敏反应、脑-肠轴改变以及导致疼痛持续的多种因素。尽管肠道炎症得到了最佳管理，但慢性腹痛仍可能持续，因此需要药物和非药物治疗方法。在IBD护理模式中整合心理支持可以减轻疾病负担和医疗成本。因此，应推荐采用与其他慢性疼痛疾病类似的多学科方法。
