Ghidotti Patrizia, Petraroia Ilaria, Fortunato Orazio, Pontis Francesca
Tumor Genomics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.
Extracell Vesicles Circ Nucl Acids. 2023 Mar 24;4(1):59-71. doi: 10.20517/evcna.2022.42. eCollection 2023.
Lung cancer is the deadliest cancer worldwide, primarily because of its metastatic spread. Extracellular vesicles (EVs) are small lipid-bilayer particles released by almost all types of cells. EVs play fundamental roles in cell-cell communication and cell-environment interactions by carrying proteins, nucleic acids such as DNA and RNA (mRNAs, lncRNAs, and miRNAs), and other bioactive molecules that are able to influence the behaviour of recipient cells. EVs have been described as key players in the modulation of tumour progression and the anticancer immune response. In this review, we highlight current knowledge on the role of non-coding RNAs in the modulation of the immune response, focusing on lung cancer. Since EVs are fundamental cell-to-cell mediators, we discuss the current knowledge on the immunomodulatory properties of tumour-derived EVs and, in particular, their ncRNA cargo during the different phases of lung cancer development and progression.
肺癌是全球最致命的癌症，主要原因是其发生转移。细胞外囊泡（EVs）是几乎所有类型细胞释放的小脂质双层颗粒。EVs通过携带蛋白质、DNA和RNA（mRNA、lncRNA和miRNA）等核酸以及其他能够影响受体细胞行为的生物活性分子，在细胞间通讯和细胞与环境相互作用中发挥重要作用。EVs已被描述为肿瘤进展调节和抗癌免疫反应中的关键参与者。在本综述中，我们重点介绍了非编码RNA在免疫反应调节中的作用的当前知识，重点是肺癌。由于EVs是细胞间的重要介质，我们讨论了肿瘤来源的EVs的免疫调节特性的当前知识，特别是它们在肺癌发生发展不同阶段的非编码RNA货物。
