Deep learning-based reconstruction: a reliability assessment in preoperative magnetic resonance imaging for primary rectal cancer.

BACKGROUND

Deep learning has developed rapidly, and deep learning reconstruction (DLR) methods in magnetic resonance imaging (MRI) are gaining attention for their potential to improve efficacy in clinical work. The preoperative MRI assessment of rectal cancer is crucial for patient management, but the imaging quality is currently limited by a number of factors. DLR could be applied to the preoperative MRI assessment of primary rectal cancer, but research about its specific reliability is limited. Thus, this study aimed to evaluate the reliability of DLR in the preoperative MRI examination of primary rectal cancer.

METHODS

This cross-sectional study was conducted at Ruijin Hospital, Shanghai Jiaotong University School of Medicine from March 2022 to October 2022. Patients with primary rectal cancer underwent routine MRI scans on a 3.0T magnetic resonance scanner (SIGNA Architect, GE Healthcare, USA) with 32-channels flexible coil with conventional reconstruction (ConR) and DLR. The DLR method had three noise reduction levels: DLR-H: 75% noise reduction reconstruction; DLR-M: 50% noise reduction reconstruction; and DLR-L: 25% noise reduction reconstruction. Three components were evaluated: objective image quality; subjective image quality; and diagnostic performance. The objective image quality assessment included the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). The subjective image quality assessment involved evaluating five subjective image quality parameters based on a 4-point Likert scale. The diagnostic performance assessment included tumour (T) staging, node (N) staging, as well as the circumferential resection margin and extramural vascular invasion evaluation. The images were evaluated in a blinded manner by two radiologists with different levels of experience. The paired sample Wilcoxon signed-rank test, Kappa test, interclass correlation coefficient, Chi-square test, Friedman test, and weighted kappa coefficients were used for the statistical analysis.

RESULTS

In total, 61 patients (mean age: 65±12 years; 38 men) were enrolled in the study. The DLR method improved the SNR and CNR values of the images relative to the ConR method, while the DLR-H produced the greatest improvement (P<0.040). The subjective image quality of the DLR-H images was superior to that of the ConR images (P<0.001), but there was no significant difference between the DLR-H and DLR-M images (P≥0.075). The evaluators showed good agreement in subjective scoring, and in the DLR image scoring, the evaluators have the best consistency in the DLR-H images scoring (kappa =0.921, P<0.001). The diagnostic efficacy of the DLR images was comparable to that of the ConR images in terms of T staging [Reader 1 (R1): P=0.603; Reader 2 (R2): P=0.206] and N staging (R1: P=0.990; R2: P=0.884).

CONCLUSIONS

The DLR method improved the quality of the images, and had comparable diagnostic efficacy without additional scanning time to that of the ConR method, and thus could be a feasible option for replacing the ConR method in the preoperative MRI examination of primary rectal cancer.