一名年轻免疫功能低下患者长期受到新冠病毒P.2变异株的慢性感染。
Long-term chronic infection of a young immunocompromised patient by the SARS-CoV-2 P.2 VOI.
作者信息
Romano Camila Malta, Silva Vitor Gabriel Lopes da, Silva Luciane Sussuchi da, Aranda Carolina Sanchez, Oliveira Cristina Mendes de, Siqueira Marilda Mendonça Teixeira, Pereira Elisa Cavalcante, Resende Paola Cristina, Bellei Nancy Cristina Junqueira, Levi José Eduardo, Moraes-Pinto Maria Isabel de
机构信息
Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo, Laboratório de Virologia (LIM-52), São Paulo, São Paulo, Brazil.
Universidade Federal de São Paulo, Departamento de Pediatria, São Paulo, São Paulo, Brazil.
出版信息
Rev Inst Med Trop Sao Paulo. 2024 Dec 6;66:e69. doi: 10.1590/S1678-9946202466069. eCollection 2024.
An immunocompromised patient was infected by the SARS-CoV-2 variant of interest named Zeta (P.2) in February 2021. More than one year later, he suffered from symptomatic COVID-19 and sequencing revealed the same variant, which accumulated 23 substitutions. This case illustrates intra-host evolution of a particular SARS-CoV-2 variant, highlighting the importance of genomic surveillance of immunocompromised patients.
一名免疫功能低下的患者于2021年2月感染了名为Zeta（P.2）的关注的SARS-CoV-2变体。一年多后，他出现了有症状的COVID-19，测序显示为同一变体，该变体积累了23个替换。该病例说明了特定SARS-CoV-2变体在宿主体内的进化，突出了对免疫功能低下患者进行基因组监测的重要性。
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