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免疫功能低下的成年患者体内的 SARS-CoV-2 脱落、感染性和进化情况。

SARS-CoV-2 shedding, infectivity, and evolution in an immunocompromised adult patient.

机构信息

Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-52), São Paulo, São Paulo, Brazil.

Universidade de São Paulo, Faculdade de Medicina, Instituto de Medicina Tropical de São Paulo (LIM-46), São Paulo, São Paulo, Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 2024 May 13;66:e28. doi: 10.1590/S1678-9946202466028. eCollection 2024.

DOI:10.1590/S1678-9946202466028
PMID:38747849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11095242/
Abstract

This study aimed to provide further insight into the evolutionary dynamics of SARS-CoV-2 by analyzing the case of a 40-year-old man who had previously undergone autologous hematopoietic stem cell transplantation due to a diffuse large B-cell lymphoma. He developed a persistent SARS-CoV-2 infection lasting at least 218 days and did not manifest a humoral immune response to the virus during this follow-up period. Whole-genome sequencing and viral cultures confirmed a persistent infection with a replication-positive virus that had undergone genetic variation for at least 196 days after symptom onset.

摘要

本研究旨在通过分析一名 40 岁男性的病例，进一步了解 SARS-CoV-2 的进化动态。该患者因弥漫性大 B 细胞淋巴瘤而接受了自体造血干细胞移植。他发生了持续的 SARS-CoV-2 感染，至少持续了 218 天，并且在此随访期间没有针对该病毒产生体液免疫反应。全基因组测序和病毒培养证实了持续感染，复制阳性的病毒在症状出现后至少 196 天发生了遗传变异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4675/11095242/fe0cce92f5d8/1678-9946-rimtsp-66-S1678-9946202466028-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4675/11095242/715e9b51c65b/1678-9946-rimtsp-66-S1678-9946202466028-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4675/11095242/fe0cce92f5d8/1678-9946-rimtsp-66-S1678-9946202466028-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4675/11095242/715e9b51c65b/1678-9946-rimtsp-66-S1678-9946202466028-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4675/11095242/fe0cce92f5d8/1678-9946-rimtsp-66-S1678-9946202466028-gf02.jpg

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