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获得性免疫缺陷综合征患者并发骨关节炎的播散性孢子丝菌病:病例报告

Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report.

作者信息

Santos Ana Paula Freitas Bahia Dos, Mota Ana Carolina de Oliveira, Jesus Gabriel Ramalho de, Rocha Matheus Dias Girão, Durço Daniela de Freitas Pereira Calheiros Ângelo, Rezende Luis Guilherme Rosifini Alves, Silva Anna Christina Tojal da, Vilar Fernando Crivelenti, Bollela Valdes Roberto, Martinez Roberto

机构信息

Faculdade de Medicina de Ribeirão Preto, Hospital das Clínicas, Departamento de Clínica Médica, Infectologia, Ribeirão Preto, SP, Brasil.

Faculdade de Medicina de Ribeirão Preto, Hospital das Clínicas, Departamento de Ortopedia, Ribeirão Preto, SP, Brasil.

出版信息

Rev Soc Bras Med Trop. 2024 Dec 16;57:e008092024. doi: 10.1590/0037-8682-0120-2024. eCollection 2024.

Abstract

Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii. The patient underwent reconstructive surgery and 9 months of treatment with amphotericin B and itraconazole, and showed complete wound healing and improved hand functionality. Suspicion of the disease is necessary in immunosuppressed patients living in endemic areas.

摘要

孢子丝菌病由孢子丝菌属真菌引起,通常通过创伤接种感染。一名26岁男性在6个月前右手出现皮损后,出现脓疱性病变并体重减轻6千克。他被诊断为获得性免疫缺陷综合征(艾滋病),骨与肌肉活检及血液样本的培养显示申克孢子丝菌生长,确诊为播散性孢子丝菌病。该患者接受了重建手术,并使用两性霉素B和伊曲康唑治疗9个月,伤口完全愈合,手部功能改善。对于生活在流行地区的免疫抑制患者,有必要怀疑该病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fb6/11654464/c9758f94d190/1678-9849-rsbmt-57-e00809-2024-gf1.jpg

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