Kasiske B L, Napier J
Am J Nephrol. 1985;5(1):45-50. doi: 10.1159/000166902.
In animals with reduced renal mass increased glomerular filtration is associated with accelerated glomerular sclerosis. Whether hyperfiltration causes glomerular damage in humans is unknown. Since increased glomerular filtration occurs in obesity, the amount of glomerular sclerosis found in renal autopsy tissue from 46 patients with massive obesity was compared to that found in 46 normal body weight controls. Despite increased kidney weight and glomerular size, obese patients had the same proportion of completely sclerosed glomeruli as controls. In addition, no focal segmental glomerular sclerosis was seen in the obese group. It is concluded that patients with massive obesity have increased kidney weight and nephron size consistent with hyperfiltration. Nevertheless, massively obese patients do not appear to have increased glomerular sclerosis.
在肾单位数量减少的动物中，肾小球滤过增加与肾小球硬化加速相关。高滤过是否会导致人类肾小球损伤尚不清楚。由于肥胖时会出现肾小球滤过增加，因此将46例重度肥胖患者肾脏尸检组织中发现的肾小球硬化量与46例正常体重对照者的进行了比较。尽管肾脏重量和肾小球大小增加，但肥胖患者完全硬化的肾小球比例与对照组相同。此外，肥胖组未观察到局灶节段性肾小球硬化。结论是，重度肥胖患者的肾脏重量和肾单位大小增加，与高滤过一致。然而，重度肥胖患者的肾小球硬化似乎并未增加。
