Salicylic acid cooperates with different small molecules to control biotic and abiotic stress responses.

Salicylic acid (SA) is a phytohormone that plays a critical role in plant growth, development, and response to unfavorable conditions. Over the past three decades, researches on SA have deeply elucidated the mechanism of its function in plants tolerance to infection by biotrophic and hemibiotrophic pathogens. Recent studies have found that SA also plays an important role in regulating plants response to abiotic stress. It is emerging as a strong tool for alleviating adverse effects of biotic and abiotic stresses in crop plants. During SA-mediated stress responses, many small molecules participate in the SA modification or signaling, which play important regulatory roles. The cooperations of small molecules in SA pathway remain least discussed, especially in terms of SA-induced abiotic stress tolerance. This review provides an overview of the recent studies about SA and its relationship with different small molecules and highlights the critical functions of small molecules in SA-mediated plant stress responses.