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自主神经反射亢进:分娩期脊髓损伤女性面临的致命危险。

Autonomic hyperreflexia: a mortal danger for spinal cord-damaged women in labor.

作者信息

McGregor J A, Meeuwsen J

出版信息

Am J Obstet Gynecol. 1985 Feb 1;151(3):330-3. doi: 10.1016/0002-9378(85)90297-2.

Abstract

Reproductive care of women with spinal cord damage demands knowledge of such women's reproductive potential and the specific complications to which these women are prone during pregnancy and childbirth, especially autonomic hyperreflexia. Fertility in cord-damaged women of reproductive age is generally undiminished as are libido, ability to have intercourse, and ability to bear children. Frequent complications of cord-damaged pregnant women include urinary tract infection, anemia, pressure sores, sepsis, unattended birth, and autonomic hyperreflexia. Autonomic hyperreflexia or autonomic dysreflexia occurs during labor in up to two thirds of women with cord lesions above T-6. Autonomic hyperreflexia results from noxious stimuli including distention of the bladder, cervix, or rectum, which evokes mass triggering of sympathetic and parasympathetic afferents that are uninhibited by supraspinal centers below the cord lesion. Autonomic hyperreflexia manifests itself with sudden onset of marked hypertension and headache during uterine contractions, as well as bradycardia or tachycardia, various cardiac dysrhythmias, and marked diaphoresis with piloerection and flushing above the level of the cord lesion. We describe the second reported occurrence of intraventricular hemorrhage due to autonomic hyperreflexia during labor and detail recommendations for anticipating and mitigating this potentially lethal complication of parturition in cord-damaged women. Pregnancy and parturition are best carried out with informed cooperation of the patient and of obstetric, cord rehabilitation, anesthetic, and nursing personnel.

摘要

为脊髓损伤女性提供生殖护理,需要了解这些女性的生殖潜能以及她们在妊娠和分娩期间易患的特定并发症,尤其是自主神经反射亢进。育龄期脊髓损伤女性的生育能力通常不受影响,性欲、性交能力和生育能力也是如此。脊髓损伤孕妇常见的并发症包括尿路感染、贫血、压疮、败血症、分娩无人照料以及自主神经反射亢进。高达三分之二的胸6以上脊髓损伤女性在分娩时会发生自主神经反射亢进或自主神经失调。自主神经反射亢进是由有害刺激引起的,包括膀胱、宫颈或直肠扩张,这会引发交感神经和副交感神经传入神经的大量触发,而脊髓损伤以下的脊髓上中枢无法抑制这些传入神经。自主神经反射亢进在子宫收缩期间表现为突然出现明显的高血压和头痛,以及心动过缓或心动过速、各种心律失常,以及脊髓损伤水平以上明显的出汗、竖毛和脸红。我们描述了第二例因分娩期间自主神经反射亢进导致的脑室内出血病例,并详细介绍了预测和减轻脊髓损伤女性分娩时这种潜在致命并发症的建议。妊娠和分娩最好在患者以及产科、脊髓康复、麻醉和护理人员的知情合作下进行。

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