Huang Cong-Ying, Liu Hao-Lin, Chang Jia-Yin, Meng Xiang-Xi, Feng Xiao-Wei, Zhuang Ya-Feng, Chen Xing-Yu, Li Min-Hui
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine Hohhot 010020, China Baotou Medical College Baotou 014040, China.
Inner Mongolia Medical University Hohhot 010110, China.
Zhongguo Zhong Yao Za Zhi. 2024 Sep;49(18):5081-5094. doi: 10.19540/j.cnki.cjcmm.20240618.101.
The genus Artemisia is one of the most abundant groups of medicinal plants in the Asteraceae family. Based on the theoretical basis of the pharmacophylogeny, the phylogenetic analysis, association analysis and other methods were used to systematically sort out the genetic relationships, properties, tastes, chemical constituents, and traditional efficacy of Mongolian medicines of genus Artemisia(MMA). The correlation and regularity were discussed. The results showed that MMA could be divided into two main groups according to phylogenetic analysis. The first group was Sect. Artemisia, which was based on bitter taste, and most of them were pungent. The proportion of warm drugs was 85.71%. The second group was the non-Artemisia group, including the medicinal plants of Sect. Absinthium, Sect. Abrotanum, Sect. Dracunculus, and Sect. Latilobus. In this group, the taste was mainly bitter, and the cold drugs accounted for 80%. The analysis of chemical constituents and medicinal tastes showed that MMA were rich in volatile oils, flavonoids, terpenoids, phenylpropanoids, and other components. Among them, the volatile oils were important sources of the unique smell of MMA. The analysis of medicinal properties and traditional efficacy showed that under the set analysis parameters, a total of 8 association rules were obtained. The association rule between cold MMA with cold and fever, the association rule between cool MMA with respiratory diseases, and the association rule between warm MMA with gynecological diseases had the highest lift value in their respective medicinal property groups. This study provides an important academic reference for establishing a new relationship between pharmacophylogeny with the tastes, properties, and traditional efficacy of medicinal materials.
蒿属是菊科中药用植物最为丰富的类群之一。基于药物系统发育学的理论基础，运用系统发育分析、关联分析等方法，对蒿属蒙药的亲缘关系、性味、化学成分及传统功效进行系统梳理，探讨其相关性及规律。结果表明，依据系统发育分析，蒿属蒙药可分为两大组。第一组为蒿组，以苦味为主，大多味辛，温性药占比85.71%。第二组为非蒿组，包括龙蒿亚属、牛尾蒿亚属、蛔蒿亚属和阔裂叶蒿亚属的药用植物。该组以苦味为主，寒性药占80%。化学成分与药味分析表明，蒿属蒙药富含挥发油、黄酮类、萜类、苯丙素类等成分，其中挥发油是蒿属蒙药独特气味的重要来源。药性与传统功效分析表明，在设定的分析参数下，共获得8条关联规则。寒性蒿属蒙药与感冒发热的关联规则、凉性蒿属蒙药与呼吸系统疾病的关联规则、温性蒿属蒙药与妇科疾病的关联规则在各自药性组中提升度值最高。本研究为建立药物系统发育学与药材性味、药性及传统功效之间的新关系提供了重要的学术参考。
