Chen Zihan, Chen Yuxiong, Li Yuanmeng, Leng Zhiwei, Li Naishi, Xia Weibo
Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
BMC Musculoskelet Disord. 2024 Dec 20;25(1):1050. doi: 10.1186/s12891-024-08190-7.
Thyroid hormone is a known pivotal factor that affects bone metabolism; however, whether bone microarchitecture is associated with thyroid hormone sensitivity is poorly understood. The trabecular bone score (TBS) serves as an essential indicator for assessing bone microarchitecture. This study aimed to investigate the relationship between sensitivity to thyroid hormones and TBS in euthyroid individuals.
This cross-sectional study involved 3320 euthyroid participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2008. Data, including thyroid function, TBS and other related parameters, were extracted and analyzed. The indices of thyroid hormone sensitivity, including the thyrotropin thyroxine resistance index (TT4RI), thyroid-stimulating hormone index (TSHI), thyroid feedback quantile-based index (TFQI) and parametric thyroid feedback quantile-based index (PTFQI), were calculated. Greater values of these indicators indicated a greater degree of impaired thyroid hormone sensitivity.
Impaired sensitivity to thyroid hormones was associated with degraded bone microarchitecture following adjustments for confounding variables (TT4RI: P = 0.005, TSHI: P = 0.008, TFQI: P = 0.003 and PTFQI: P = 0.006). The restricted cubic spline model demonstrated a positive relationship between TT4RI, TSHI, TFQI, PTFQI and degraded bone microarchitecture. Similar findings were observed in the analysis of subgroups stratified by age, sex, race, diabetes status, hypertension status and hyperuricemia status.
In euthyroid individuals, impaired sensitivity to thyroid hormones is associated with degraded bone microarchitecture. However, further studies are required to confirm this relationship.
甲状腺激素是影响骨代谢的关键因素；然而，骨微结构与甲状腺激素敏感性之间的关系却鲜为人知。骨小梁骨评分（TBS）是评估骨微结构的重要指标。本研究旨在探讨甲状腺功能正常个体中甲状腺激素敏感性与TBS之间的关系。
这项横断面研究纳入了2007 - 2008年美国国家健康与营养检查调查（NHANES）中的3320名甲状腺功能正常的参与者。提取并分析了包括甲状腺功能、TBS和其他相关参数的数据。计算了甲状腺激素敏感性指标，包括促甲状腺素甲状腺素抵抗指数（TT4RI）、促甲状腺激素指数（TSHI）、基于甲状腺反馈分位数的指数（TFQI）和基于参数化甲状腺反馈分位数的指数（PTFQI）。这些指标的值越大，表明甲状腺激素敏感性受损程度越高。
在对混杂变量进行调整后，甲状腺激素敏感性受损与骨微结构退化相关（TT4RI：P = 0.005，TSHI：P = 0.008，TFQI：P = 0.003，PTFQI：P = 0.006）。受限立方样条模型显示TT4RI、TSHI、TFQI、PTFQI与骨微结构退化呈正相关。在按年龄、性别、种族、糖尿病状态、高血压状态和高尿酸血症状态分层的亚组分析中也观察到了类似的结果。
在甲状腺功能正常的个体中，甲状腺激素敏感性受损与骨微结构退化有关。然而，需要进一步的研究来证实这种关系。
