Arefhosseini Sara, Tutunchi Helda, Arefhosseini Seyed Rafie, Ghavami Seyede Zoha, Ebrahimi-Mameghani Mehrangiz
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Res Notes. 2024 Dec 19;17(1):370. doi: 10.1186/s13104-024-07025-x.
This study investigated copper (Cu) status in relation to abdominal obesity indices and liver function in patients with non-alcoholic fatty liver disease (NAFLD). This case-control study was carried out on 80 overweight/obese patients with NAFLD and 80 apparently healthy age, sex, and body mass index (BMI)-matched controls. A validated and reliable 168-item semi-quantitative food frequency questionnaire was completed for each subject and fasting serum levels of liver aminotransferases, ferritin, Cu and ceruloplasmin were assessed.
Mean intakes of energy and carbophydrate were significantly lower in patients with NAFLD than the control group while mean protein intake was highre (p < 0.05). Although mean Cu intake was greater in cases than controls, low dietary intake of Cu was found in 7.5% and 32.5% of the cases and controls, respectively. Apart from serum levels of liver aminotransferases (p < 0.001) and ferritin (p = 0.010), no significant differences were found in serum levels of Cu and ceruloplasmin. Serum and dietary Cu were positively correlated with obesity indices and serum ceruloplasmin was correlated with waist to height ratio and ferritin only in cases (p < 0.05). Low Cu intake (< 0.95 mg/day) was more likely to increase the odds of NAFLD (p for trend = 0.002), after adjusting for potential confounders.
本研究调查了非酒精性脂肪性肝病（NAFLD）患者的铜（Cu）状态与腹部肥胖指数及肝功能的关系。本病例对照研究纳入了80例超重/肥胖的NAFLD患者以及80例年龄、性别和体重指数（BMI）相匹配的明显健康的对照者。为每位受试者完成了一份经过验证且可靠的包含168个条目的半定量食物频率问卷，并评估了空腹血清肝转氨酶、铁蛋白、铜和铜蓝蛋白水平。
NAFLD患者的能量和碳水化合物平均摄入量显著低于对照组，而蛋白质平均摄入量更高（p<0.05）。尽管病例组的铜平均摄入量高于对照组，但分别有7.5%的病例和32.5%的对照者存在低铜饮食摄入情况。除血清肝转氨酶水平（p<0.001）和铁蛋白水平（p=0.010）外，铜和铜蓝蛋白的血清水平未发现显著差异。血清铜和膳食铜与肥胖指数呈正相关，且仅在病例组中血清铜蓝蛋白与腰高比和铁蛋白相关（p<0.05）。在调整潜在混杂因素后，低铜摄入量（<0.95毫克/天）更有可能增加患NAFLD的几率（趋势p=0.002）。
