BACKGROUND: Stroke is a common disease that poses a significant threat to human health. Approximately one-third of stroke patients experience poststroke cognitive impairment (PSCI), which severely impacts their quality of life and survival time. Although the prevalence and risk factors for PSCI have been widely reported, these results have not been synthesized. OBJECTIVES: This systematic review was conducted to explore the prevalence and risk factors of PSCI. METHODS: PubMed, EMBASE, Web of Science, and Cochrane Library were comprehensively searched for studies exploring the prevalence and risk factors of PSCI from inception to July 5, 2022. RESULTS: A total of 49 articles were included for meta-analysis. It was found that the combined prevalence of PSCI was 39%-47%. Risk factors for PSCI include female gender, age, education level less than 7 years, atrial fibrillation, diabetes, smoking, drinking, hypertension, coronary artery disease, carotid artery plaque, admission NIHSS score ≥ 5, unemployment, and homocysteine. CONCLUSIONS: This systematic review has revealed a combined prevalence of PSCI is ranging from 39% to 47% and identified several risk factors for PSCI. These findings indicate a high incidence of the condition and underscore the need for increased public awareness. Future investigations should prioritize the identification of PSCI risk factors, providing a theoretical basis for nursing professionals to effectively manage and treat PSCI patients.