Gubler D J, Kuno G, Sather G E, Waterman S H
Am J Trop Med Hyg. 1985 Jan;34(1):170-3. doi: 10.4269/ajtmh.1985.34.170.
The first documented case of concurrent human infection with 2 dengue viruses is reported. Dengue 1 and 4 viruses were isolated from the serum of a 16-year-old male during the 1982 outbreak in Puerto Rico. The illness was mild and does not support the hypothesis that double infection with dengue viruses leads to more severe hemorrhagic disease.
据报道,首例人类同时感染两种登革病毒的病例有文献记载。在1982年波多黎各的疫情爆发期间,从一名16岁男性的血清中分离出了登革1型和4型病毒。该病例病情较轻,不支持登革病毒双重感染会导致更严重出血性疾病这一假说。