Kopylev Leonid, Dzierlenga Michael, Lin Yu-Sheng, Nachman Rebecca, Radke Elizabeth, Ru Hongyu, Segal Deborah
Center for Public Health and Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, USA.
J Toxicol Environ Health B Crit Rev. 2025 May 19;28(4):223-232. doi: 10.1080/10937404.2024.2444650. Epub 2024 Dec 20.
Developmental neurotoxicity (DNT) is a well-established hazard attributed to methylmercury (MeHg) exposure. This evidence is based primarily upon includes studies that measured biomarkers of MeHg exposure in samples of maternal hair and blood, and cord blood. The aim of this review was to investigate which of these prenatal biomarkers is most appropriate for quantifying the DNT effects attributed to MeHg. A comprehensive literature search covered MeHg dose-response literature published 1998-2022. Studies were evaluated for risk of bias and study sensitivity using IRIS approach. Quantitative results of investigations were extracted and statistically compared. Seven studies were identified that measured both maternal hair and cord blood Hg levels. In these investigations, several DNT umbrella tests and their sub-tests results were modeled. Cord blood MeHg was more sensitive, producing larger estimates of MeHg potency, in most of the comparisons (91%) with maternal hair MeHg estimates for the same sub-tests in the same study. When comparing results from cord blood Hg to maternal hair Hg there was a 75% increase in sensitivity (range: 4-583%). In the two domains where results for maternal hair Hg were more sensitive, the rise was only 18% (Range: 7-29%). There were limited data (two studies) that compared maternal blood and maternal hair biomarkers (maternal blood Hg was more sensitive (mean 320% and range 43-855%) and cord blood biomarkers (maternal blood Hg was more sensitive by approximately 30%). Maternal hair Hg remains an appropriate biomarker for exposure monitoring in many populations, but these data suggest that cord blood Hg is more appropriate for dose-response modeling of MeHg DNT effects.
发育神经毒性（DNT）是一种公认的由甲基汞（MeHg）暴露所致的危害。这一证据主要基于对孕妇头发、血液及脐带血样本中MeHg暴露生物标志物的测量研究。本综述的目的是探究这些产前生物标志物中哪一种最适合用于量化MeHg所致的DNT效应。全面的文献检索涵盖了1998年至2022年发表的MeHg剂量反应文献。采用IRIS方法对研究的偏倚风险和研究敏感性进行评估。提取调查的定量结果并进行统计学比较。确定了七项同时测量孕妇头发和脐带血汞水平的研究。在这些调查中，对几项DNT综合测试及其子测试结果进行了建模。在同一研究中，对于相同子测试，与孕妇头发MeHg估计值相比，脐带血MeHg在大多数比较（91%）中更敏感，产生的MeHg效力估计值更大。当比较脐带血汞与孕妇头发汞的结果时，敏感性提高了75%（范围：4 - 583%）。在孕妇头发汞结果更敏感的两个领域，增幅仅为18%（范围：7 - 29%）。比较孕妇血液和孕妇头发生物标志物（孕妇血液汞更敏感（平均320%，范围43 - 855%））以及脐带血生物标志物（孕妇血液汞敏感约30%）的数据有限（两项研究）。孕妇头发汞在许多人群中仍然是用于暴露监测的合适生物标志物，但这些数据表明脐带血汞更适合用于MeHg DNT效应的剂量反应建模。
