Samadi Parisa, Alipour Zahra, Ghaedrahmati Maryam, Vahedian Mostafa
Department of Reproductive Health, School of Nursing and Midwifery, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Midwifery, School of Nursing and Midwifery, Qom University of Medical Sciences. Qom, Iran.
Tanaffos. 2024 Jan;23(1):73-82.
Due to the high prevalence of COVID-19 and the prevention and control of adverse fetal and neonatal outcomes in pregnant women, including vertical transmission, this study was performed to describe the fetal and neonatal outcomes of pregnancy with a spectrum of COVID-19 disease during pregnancy in Iran.
In this cross-sectional study, we analyzed the medical records of 258 pregnant women admitted to the Forghani Hospital, Qom, Iran, from 18 February 2020, to May 10, 2021. PCR-RT or respiratory compromise in the presence of marked radiographic changes of COVID-19 in the lungs, or both COVID-19 disease confirmed COVID-19 disease. Then, we collected the disease spectrum of COVID-19 and fetal and neonatal outcomes from patient records.
The findings of our study showed that out of 258 pregnant women who were hospitalized due to COVID-19, 79.8% had mild to moderate disease, 16.7% had severe COVID-19, and 3.5% were in the critical stage. After adjusting for the confounding variables, the severity of the disease was significantly associated with adverse fetal and neonatal outcomes such as fetal distress, Intra Uterine Growth Restriction (IUGR), preterm delivery, and Low Birth Weight (LBW), and low first minute Apgar score. However, the severity of COVID-19 was not a predictor of spontaneous preterm delivery, admission to NICU, low Apgar scores at 5 minutes, vertical transmission, stillbirth, and neonatal death.
Neonates of mothers with the severe and critical stage of COVID-19 are exposed to higher potential risks such as fetal distress, IUGR, preterm delivery, LBW, and low Apgar scores at 1 minute than women with mild to moderate disease.
由于新冠病毒病（COVID-19）的高流行率以及对孕妇不良胎儿和新生儿结局（包括垂直传播）的预防和控制，本研究旨在描述伊朗孕期感染不同程度COVID-19疾病的孕妇的胎儿和新生儿结局。
在这项横断面研究中，我们分析了2020年2月18日至2021年5月10日期间入住伊朗库姆福尔加尼医院的258名孕妇的病历。PCR-RT检测或肺部出现明显COVID-19影像学改变时的呼吸功能不全，或两者均证实为COVID-19疾病。然后，我们从患者记录中收集了COVID-19的疾病谱以及胎儿和新生儿结局。
我们的研究结果显示，在因COVID-19住院的258名孕妇中，79.8%患有轻度至中度疾病，16.7%患有重度COVID-19，3.5%处于危重症阶段。在对混杂变量进行校正后，疾病严重程度与胎儿窘迫、胎儿宫内生长受限（IUGR）、早产、低出生体重（LBW）以及1分钟时低阿氏评分等不良胎儿和新生儿结局显著相关。然而，COVID-19的严重程度并非自发性早产、入住新生儿重症监护病房（NICU）、5分钟时低阿氏评分、垂直传播、死产和新生儿死亡的预测因素。
与患有轻度至中度疾病的孕妇相比，处于COVID-19重症和危重症阶段的母亲所生新生儿面临更高的潜在风险（如胎儿窘迫、IUGR、早产、LBW以及1分钟时低阿氏评分）。
