Imade Emmanuel Edoghogho, Obayagbona Nosa Omoregbe
Department of Microbiology, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
Department of Nursing and Community Health, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland.
Gut Microbiome (Camb). 2024 May 2;5:e13. doi: 10.1017/gmb.2024.3. eCollection 2024.
The gut microbiota (GM) comprises microorganisms in the human gastrointestinal tract (GIT). Lifestyle choices like smoking lead to gut dysbiosis. This review assessed the effect of cigarette smoke (CS) on gut microbial dysbiosis (GMD) in active smokers compared to non-smokers, as well as the resulting public health implications. A comprehensive search was conducted using the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, and PubMed. The search result was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The Critical Appraisal Skills Programme (CASP) tool was used to evaluate the recruited studies. There were 468 articles found, with 17 of them qualifying for full-text screening. Five of these studies were included in the review. Smoke harmed gut microbe proportions; smokers had more Bacteroidetes and less Firmicutes than non-smokers, affecting their Firmicutes/Bacteroidetes (Fir/Bac) ratio. This has significant public health implications. Organisms enriched in the smokers such as , pH 8, and were found to be positively correlated with inflammatory biomarkers. Other organisms, such as , and were negatively correlated with inflammatory markers and were more in non-smokers.
肠道微生物群（GM）由人类胃肠道（GIT）中的微生物组成。吸烟等生活方式选择会导致肠道生态失调。本综述评估了与非吸烟者相比，香烟烟雾（CS）对主动吸烟者肠道微生物失调（GMD）的影响以及由此产生的公共卫生影响。使用护理及相关健康文献累积索引（CINAHL）、医学文献数据库（Medline）和PubMed进行了全面检索。检索结果按照系统评价和Meta分析的首选报告项目（PRISMA）2020指南进行报告。使用批判性评估技能计划（CASP）工具对纳入的研究进行评估。共找到468篇文章，其中17篇符合全文筛选条件。本综述纳入了其中5项研究。烟雾损害了肠道微生物比例；吸烟者的拟杆菌门比非吸烟者更多，厚壁菌门比非吸烟者更少，影响了他们的厚壁菌门/拟杆菌门（Fir/Bac）比率。这具有重大的公共卫生意义。在吸烟者中富集的微生物，如pH 8以及，被发现与炎症生物标志物呈正相关。其他微生物，如以及，与炎症标志物呈负相关，且在非吸烟者中更多。
