Reverte-Pagola Gonzalo, Sánchez-Trigo Horacio, Saxton John, Sañudo Borja
Department of Physical Education and Sport, Universidad de Sevilla, 41012 Sevilla, Spain.
Department of Sport, Health and Exercise Science, Faculty of Health Sciences, University of Hull, Hull HU6 7RX, UK.
Cancers (Basel). 2022 Jul 14;14(14):3428. doi: 10.3390/cancers14143428.
Physical exercise is considered to be a non-pharmacological strategy for reducing symptoms of cancer-related fatigue (CRF) in women with breast cancer (BC). This systematic review and meta-analysis aims to assess the effects of non-supervised exercise programs in comparison with the effects of supervised exercise interventions for CRF in BC patients. Randomized controlled trials that investigated the effect of exercise on CRF in women were searched for until 29 June 2022. Inclusion criteria comprised women diagnosed with BC; exercise-based interventions; trials comparing at least one exercise group vs. a control group; trials that assessed exercise effects on CRF. Thirty-one studies met the inclusion criteria (n = 2964). Both non-supervised and supervised exercise programs significantly reduced CRF (standard mean difference (SMD) = −0.46, confidence interval (CI) = (−0.64, −0.28), p < 0.0001 and SMD = −0.74, CI = (−0.99, −0.48), p < 0.0001, respectively), without statistical difference (p = 0.09). However, a short-term training program subgroup analyses showed significant differences between supervised and non-supervised training programs (p = 0.01), showing that supervised training programs have a greater effect (SMD = −1.33, CI = (−1.92, −0.73), p < 0.0001) than non-supervised ones (SMD = −0.44, CI = (−0.78, −0.11), p = 0.009). Both supervised and non-supervised exercise programs may reduce CRF in BC patients; however, in the short-term, supervised exercise may have a greater effect on CRF in BC patients.
体育锻炼被认为是一种非药物策略，用于减轻乳腺癌（BC）女性患者的癌症相关疲劳（CRF）症状。本系统评价和荟萃分析旨在评估非监督运动计划与监督运动干预对BC患者CRF的影响。检索了截至2022年6月29日调查运动对女性CRF影响的随机对照试验。纳入标准包括被诊断为BC的女性；基于运动的干预措施；比较至少一个运动组与对照组的试验；评估运动对CRF影响的试验。31项研究符合纳入标准（n = 2964）。非监督和监督运动计划均显著降低了CRF（标准化均数差（SMD）= -0.46，置信区间（CI）=（-0.64，-0.28），p < 0.0001和SMD = -0.74，CI =（-0.99，-0.48），p < 0.0001），无统计学差异（p = 0.09）。然而，短期训练计划亚组分析显示监督和非监督训练计划之间存在显著差异（p = 0.01），表明监督训练计划比非监督训练计划有更大的效果（SMD = -1.33，CI =（-1.92，-0.73），p < 0.0001）（SMD = -0.44，CI =（-0.78，-0.11），p = 0.009）。监督和非监督运动计划均可降低BC患者的CRF；然而，在短期内，监督运动对BC患者的CRF可能有更大的影响。
