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胃癌相关外泌体的研究趋势与热点：一项文献计量学分析

Research trends and hotspots in gastric carcinoma associated exosome: a bibliometric analysis.

作者信息

Liu Chunqiu, Guo Honglei, Jin Fangzhou

机构信息

Integrated Traditional Chinese and Western Medicine Oncology Department, Tangshan People's Hospital, Tangshan, Hebei, China.

Department of Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, China.

出版信息

Front Oncol. 2024 Dec 5;14:1457346. doi: 10.3389/fonc.2024.1457346. eCollection 2024.

DOI:10.3389/fonc.2024.1457346
PMID:39703839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11655325/
Abstract

BACKGROUND

Stomach cancer is considered the fifth most common cancer worldwide. This study utilized bibliometric analysis to construct a visualization map of the relationship between stomach cancer and exosomes, aiming to reveal research trends and emerging themes, and provide direction for future research.

METHOD

Retrieve relevant literature on gastric cancer exosomes in the Web of Science Core Collection (WoSCC) over the past 25 years according to search criteria, and conduct bibliometric and visualization analysis using bibliometric software VOSviewer and CiteSpace.

RESULTS

This study included a total of 727 articles, with an overall increasing trend in annual publication output. There were 68 countries involved, with China having the largest number of publications followed by the United States. A total of 957 research institutions were involved, with most of the top 10 institutions in terms of publication output being universities in China. The top 5 journals are Molecular Cancer, Cell death & disease, Cancers, International journal of molecular sciences, and Frontiers in oncology. A total of 4529 authors were involved, with 5 authors having a publication output of no less than 13 articles. A total of 35516 references were cited, with a total number of citations. The top publication is "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells".

CONCLUSION

Over the past 25 years, researchers have been dedicated to studying the field of exosomes related to gastric cancer, and research in this area is currently progressing steadily. Based on previous studies, exosomes in gastric adenocarcinoma serve as biomarkers, potential therapeutic targets, and post-resistance treatment, which represents current hotspots and emerging frontiers in research.

摘要

背景

胃癌被认为是全球第五大常见癌症。本研究利用文献计量分析构建胃癌与外泌体之间关系的可视化图谱，旨在揭示研究趋势和新兴主题，并为未来研究提供方向。

方法

根据检索标准，在过去25年的科学网核心合集（WoSCC）中检索有关胃癌外泌体的相关文献，并使用文献计量软件VOSviewer和CiteSpace进行文献计量和可视化分析。

结果

本研究共纳入727篇文章，年发表量总体呈上升趋势。涉及68个国家，中国发表的文章数量最多，其次是美国。共涉及957个研究机构，发表量排名前十的机构大多是中国的大学。排名前五的期刊是《分子癌症》《细胞死亡与疾病》《癌症》《国际分子科学杂志》和《肿瘤学前沿》。共涉及4529位作者，有5位作者的发表量不少于13篇文章。共引用了35516篇参考文献，总被引次数。被引次数最多的文献是“外泌体介导的mRNA和微小RNA转移是细胞间基因交换的新机制”。

结论

在过去25年中，研究人员一直致力于研究与胃癌相关的外泌体领域，该领域的研究目前正在稳步推进。基于以往的研究，胃腺癌中的外泌体可作为生物标志物、潜在的治疗靶点和耐药后治疗，这代表了当前研究的热点和新兴前沿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/c5f0243df27b/fonc-14-1457346-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/525485545413/fonc-14-1457346-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/f7274d2a1db6/fonc-14-1457346-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/9bf4fa49fbd0/fonc-14-1457346-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/c69c53f9c127/fonc-14-1457346-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/f3025b264088/fonc-14-1457346-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/727e55c7ea58/fonc-14-1457346-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/87be8d1191af/fonc-14-1457346-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/756adb52a73d/fonc-14-1457346-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/c5f0243df27b/fonc-14-1457346-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/525485545413/fonc-14-1457346-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/f7274d2a1db6/fonc-14-1457346-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/9bf4fa49fbd0/fonc-14-1457346-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/c69c53f9c127/fonc-14-1457346-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/f3025b264088/fonc-14-1457346-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/727e55c7ea58/fonc-14-1457346-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/87be8d1191af/fonc-14-1457346-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/756adb52a73d/fonc-14-1457346-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6ad4/11655325/c5f0243df27b/fonc-14-1457346-g009.jpg

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本文引用的文献

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Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.外泌体 circATP8A1 通过调控 miR-1-3p/STAT6 轴诱导巨噬细胞 M2 极化促进胃癌进展。
Mol Cancer. 2024 Mar 8;23(1):49. doi: 10.1186/s12943-024-01966-4.
2
CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.环状 RNA 葡萄糖调节蛋白 78 相互作用蛋白 3 通过调控 miR-1343-3p/PGK1 通路并抑制波形蛋白磷酸化促进胃癌进展。
J Transl Med. 2024 Mar 8;22(1):251. doi: 10.1186/s12967-023-04625-2.
3
Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells.
胃癌分泌的 miR-214-3p 通过抑制血管内皮细胞中的铁死亡来抑制阿帕替尼的抗血管生成作用。
Oncol Res. 2024 Feb 6;32(3):489-502. doi: 10.32604/or.2023.046676. eCollection 2024.
4
Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles.胃癌与间充质干细胞衍生的外泌体：从促肿瘤生成作用到抗肿瘤载体。
Arch Pharm Res. 2024 Jan;47(1):1-19. doi: 10.1007/s12272-023-01477-8. Epub 2023 Dec 27.
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Exosomes-mediated transfer of LINC00691 regulates the formation of CAFs and promotes the progression of gastric cancer.外泌体介导的 LINC00691 转移调节 CAFs 的形成并促进胃癌的进展。
BMC Cancer. 2023 Oct 2;23(1):928. doi: 10.1186/s12885-023-11373-5.
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A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer.胃癌顺铂耐药的潜在分子机制及药物干预/纳米治疗的研究进展。
Biomed Pharmacother. 2023 Oct;166:115337. doi: 10.1016/j.biopha.2023.115337. Epub 2023 Sep 4.
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SALL4 promotes angiogenesis in gastric cancer by regulating VEGF expression and targeting SALL4/VEGF pathway inhibits cancer progression.SALL4通过调节VEGF表达促进胃癌血管生成，靶向SALL4/VEGF通路可抑制癌症进展。
Cancer Cell Int. 2023 Jul 31;23(1):149. doi: 10.1186/s12935-023-02985-9.
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A nine-gene signature as prognostic biomarker in gastric cancer by bioinformatics analysis.通过生物信息学分析确定一个九基因特征作为胃癌的预后生物标志物
Clin Transl Oncol. 2023 Nov;25(11):3296-3306. doi: 10.1007/s12094-023-03180-y. Epub 2023 Apr 11.
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Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer.癌症相关成纤维细胞衍生的外泌体DACT3-AS1缺失促进胃癌的恶性转化和铁死亡介导的奥沙利铂耐药。
Drug Resist Updat. 2023 May;68:100936. doi: 10.1016/j.drup.2023.100936. Epub 2023 Jan 31.
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