Channing Division of Network Medicine, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.
Department of Neurosurgery, Computational Neuroscience Outcomes Center, Brigham and Women's Hospital, Boston, MA, USA.
Eur J Epidemiol. 2021 Sep;36(9):965-974. doi: 10.1007/s10654-021-00800-1. Epub 2021 Sep 4.
The association between alcohol intake and glioma remains unclear. We evaluated the association between alcohol intake and incidence of glioma in three large, prospective cohort studies with repeated alcohol assessments.
We harnessed data from three studies with repeat alcohol assessment to compute hazard ratios (HR) and 95% confidence intervals (CI) for glioma by overall alcohol intake and intake from specific beverages using Cox proportional hazards regression, adjusted for age, cohort, body mass index, smoking status, and caloric intake. Analyses were conducted separately for glioma overall and for glioblastoma (GBM).
We confirmed 554 incident glioma cases (362 GBM) among 237,505 participants with 6,216,378 person-years of follow up. Cumulative average alcohol intake was associated with reduced risk of glioma (HR = 0.75, 95%CI:0.56-0.99 comparing > 8-15 to ≤ 0.5 g/d; HR = 0.71, 95%CI:0.53-0.96 comparing > 15 g/d to ≤ 0.5 g/d). When stratified by sex, for the same comparisons, the HRs for men were 0.57 (95%CI:0.36-0.89) and 0.79 (0.53-1.16), and for women 0.90 (95%CI:0.62-1.30) and 0.62, 95%CI:0.39-0.97. Results were consistent when examining cumulative average, baseline, and recent intake, and with a 4 year lag.
These results provide evidence against a positive association between alcohol intake and glioma risk. Alcohol intake was associated with reduced risk of glioma in both men and women.
饮酒与脑胶质瘤之间的关联仍不明确。我们评估了三次大型前瞻性队列研究中，通过重复饮酒评估，总体饮酒量及特定饮料饮酒量与脑胶质瘤发病率之间的关联。
我们利用具有重复饮酒评估的三项研究的数据，采用 Cox 比例风险回归计算了总体饮酒量和特定饮料饮酒量与脑胶质瘤（包括胶质母细胞瘤）风险的危害比（HR）和 95%置信区间（CI），调整因素包括年龄、队列、体重指数、吸烟状况和热量摄入。对脑胶质瘤整体和胶质母细胞瘤分别进行了分析。
我们在 237505 名参与者中确认了 554 例脑胶质瘤病例（362 例胶质母细胞瘤），随访时间为 6216378 人年。累积平均饮酒量与脑胶质瘤风险降低相关（HR=0.75，95%CI：0.56-0.99，比较>8-15 与≤0.5 g/d；HR=0.71，95%CI：0.53-0.96，比较>15 g/d 与≤0.5 g/d）。按性别分层，对于相同的比较，男性的 HR 分别为 0.57（95%CI：0.36-0.89）和 0.79（0.53-1.16），女性的 HR 分别为 0.90（95%CI：0.62-1.30）和 0.62（95%CI：0.39-0.97）。观察累积平均、基线和近期饮酒量以及 4 年潜伏期时，结果一致。
这些结果提供了饮酒与脑胶质瘤风险之间无关联的证据。在男性和女性中，饮酒与脑胶质瘤风险降低相关。
