Nie Yuhui, Song Chen, Wang Jingru, Wu Kun, Yu Mingxin, Shen Xin, Bian Yandong, Liu Shuzhen
School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Weifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.
Front Oncol. 2024 Dec 5;14:1473881. doi: 10.3389/fonc.2024.1473881. eCollection 2024.
Male breast cancer represents only 1% of all breast malignancies, with ectopic breast cancer in men being even rarer and highly prone to diagnostic challenges. Extramammary Paget's disease (EMPD), a rare cutaneous tumor with non-specific clinical symptoms, is susceptible to misdiagnosis. This report discusses the case of an older male patient who presented with a scrotal mass, later identified as ectopic breast invasive adenocarcinoma upon pathological examination post-lesion excision. Immunohistochemistry confirmed a triple-negative profile and EMPD diagnosis, with no malignancies detected in either breast. Despite multiple treatment regimens and recurrence following adjuvant chemotherapy, the disease progressed with associated chemotherapy-related side effects, resulting in a 25.5-month survival period. The scarcity of literature on male ectopic breast cancer complicates the understanding of its incidence and optimal treatment strategies, increasing the risk of misdiagnosis. This study highlights the diagnostic and therapeutic challenges of this rare case, emphasizing the need for early recognition of atypical manifestations. The manuscript aims to assist clinicians by sharing case-specific insights and reviewing pertinent literature to enhance comprehension and management of similarly rare cases.
男性乳腺癌仅占所有乳腺恶性肿瘤的1%，男性异位乳腺癌更为罕见，极易引发诊断难题。乳房外佩吉特病（EMPD）是一种罕见的皮肤肿瘤，临床症状不具特异性，容易误诊。本报告讨论了一例老年男性患者的病例，该患者阴囊出现肿物，病变切除后经病理检查确诊为异位乳腺浸润性腺癌。免疫组化证实为三阴性特征且诊断为EMPD，双侧乳房均未检测到恶性肿瘤。尽管采用了多种治疗方案且辅助化疗后复发，但疾病仍进展并伴有化疗相关副作用，导致生存期为25.5个月。关于男性异位乳腺癌的文献稀缺，这使得人们对其发病率和最佳治疗策略的理解变得复杂，增加了误诊风险。本研究突出了这一罕见病例的诊断和治疗挑战，强调了早期识别非典型表现的必要性。本文旨在通过分享具体病例见解并回顾相关文献，帮助临床医生提高对类似罕见病例的理解和管理能力。
