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一例罕见的功能性转移性滤泡状甲状腺癌伴甲状腺毒症病例。

A Rare Case of Functional Metastatic Follicular Thyroid Carcinoma With Concomitant Thyrotoxicosis.

作者信息

Chin Yun Ann, Sumbul Zaheer, Teh Yi Lin, Chng Chiaw Ling

机构信息

Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.

Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore, Singapore.

出版信息

Case Rep Endocrinol. 2024 Dec 12;2024:1398125. doi: 10.1155/crie/1398125. eCollection 2024.

DOI:10.1155/crie/1398125
PMID:39703928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11658849/
Abstract

We report a case of a 60-year-old lady with metastatic follicular thyroid carcinoma (FTC) who was presented with thyrotoxicosis and heart failure symptoms after total thyroidectomy. Clinical features and investigations led to the diagnosis of functional metastatic FTC with concomitant thyrotoxicosis. Levothyroxine therapy was stopped, and she was treated with propylthiouracil (PTU) followed by serial radioiodine treatments (RAITs) with good control of thyrotoxicosis and metastases. Despite having a very high disease burden with metastatic FTC, she has been able to maintain her functional status thus far, 4.5 years after initial diagnosis.

摘要

我们报告一例60岁女性转移性滤泡状甲状腺癌（FTC）患者，该患者在全甲状腺切除术后出现甲状腺毒症和心力衰竭症状。临床特征及检查结果确诊为功能性转移性FTC伴甲状腺毒症。停用左甲状腺素治疗，给予丙硫氧嘧啶（PTU）治疗，随后进行系列放射性碘治疗（RAITs），甲状腺毒症和转移灶得到良好控制。尽管转移性FTC疾病负担极高，但自初次诊断以来4.5年，她至今仍能维持其功能状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/0655c34bed67/CRIE2024-1398125.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/fff60bee04a1/CRIE2024-1398125.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/a9cd9ad8c7e5/CRIE2024-1398125.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/9e899e5c85bc/CRIE2024-1398125.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/e4fc67348639/CRIE2024-1398125.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/730442b9773d/CRIE2024-1398125.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/f00c6a51f46b/CRIE2024-1398125.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/0655c34bed67/CRIE2024-1398125.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/fff60bee04a1/CRIE2024-1398125.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/a9cd9ad8c7e5/CRIE2024-1398125.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/9e899e5c85bc/CRIE2024-1398125.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/e4fc67348639/CRIE2024-1398125.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/730442b9773d/CRIE2024-1398125.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/f00c6a51f46b/CRIE2024-1398125.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b34/11658849/0655c34bed67/CRIE2024-1398125.007.jpg

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本文引用的文献

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Radiol Oncol. 2023 Sep 4;57(3):380-388. doi: 10.2478/raon-2023-0034. eCollection 2023 Sep 1.
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Risk Factors and Prognosis for Metastatic Follicular Thyroid Cancer.滤泡性甲状腺癌转移的风险因素和预后。
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De Novo Extra-Thyroidal Manifestations of Graves' Disease presenting 16 Years after Total Thyroidectomy for Thyroid Cancer.
甲状腺癌全甲状腺切除术后16年出现的Graves病新发甲状腺外表现
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An Unusual Case of Metastatic Functional Thyroid Carcinoma With a Remarkable Treatment Response to Radioactive Iodine.一例罕见的转移性功能性甲状腺癌对放射性碘治疗反应显著的病例
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Endocr J. 2017 Dec 28;64(12):1143-1147. doi: 10.1507/endocrj.EJ17-0220. Epub 2017 Sep 5.
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2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.2015年美国甲状腺协会成人甲状腺结节和分化型甲状腺癌管理指南：美国甲状腺协会甲状腺结节和分化型甲状腺癌指南工作组
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