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特发性嗜酸性粒细胞增多症合并隐球菌性脑膜炎：一例报告

Idiopathic eosinophilia complicated with cryptococcal meningitis: a case report.

作者信息

Liu Zhongshuo, Lou Ying, Ji Yingxiao, Zhao Congying, Li Litao

机构信息

Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.

Hebei Medical University, Shijiazhuang, Hebei, China.

出版信息

J Int Med Res. 2024 Dec;52(12):3000605241305437. doi: 10.1177/03000605241305437.

DOI:10.1177/03000605241305437
PMID:39703993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11662334/
Abstract

Idiopathic eosinophilia, characterized by unexplained peripheral blood eosinophilia after ruling out secondary causes, is an extremely rare condition. Cryptococcal meningitis is a life-threatening opportunistic infection that primarily affects immunocompromised individuals, such as those with advanced AIDS or leukemia. In this report, we present a unique case of idiopathic eosinophilia concurrent with cryptococcal meningitis, which, to the best of our knowledge, is the first such case described globally.

摘要

特发性嗜酸性粒细胞增多症是一种极为罕见的病症，其特征为在排除继发原因后出现不明原因的外周血嗜酸性粒细胞增多。隐球菌性脑膜炎是一种危及生命的机会性感染，主要影响免疫功能低下的个体，如晚期艾滋病患者或白血病患者。在本报告中，我们呈现了一例特发性嗜酸性粒细胞增多症并发隐球菌性脑膜炎的独特病例，据我们所知，这是全球首例此类病例的描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/5437a319b93a/10.1177_03000605241305437-fig11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/5437a319b93a/10.1177_03000605241305437-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/c181737ed37b/10.1177_03000605241305437-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/0627371c70bd/10.1177_03000605241305437-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/6933c841cc7e/10.1177_03000605241305437-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/c510d4e1c92b/10.1177_03000605241305437-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/2c42fb531533/10.1177_03000605241305437-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/c66d67d71bd4/10.1177_03000605241305437-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/f78a6f106ceb/10.1177_03000605241305437-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/bd3bf324895e/10.1177_03000605241305437-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/b7adc744963b/10.1177_03000605241305437-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/2d46f6f1261f/10.1177_03000605241305437-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b393/11662334/5437a319b93a/10.1177_03000605241305437-fig11.jpg

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本文引用的文献

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Glucocorticoids as a risk factor for infection and adverse outcomes in non-HIV and non-transplant patients with cryptococcal meningitis.糖皮质激素作为非 HIV 和非移植患者隐球菌性脑膜炎感染和不良结局的危险因素。
Mycoses. 2024 Mar;67(3):e13709. doi: 10.1111/myc.13709.
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Biologics and Hypereosinophilic Syndromes: Knowledge Gaps and Controversies.生物制剂与嗜酸性粒细胞增多综合征：知识空白与争议
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Molecular typing and antifungal susceptibility of clinical isolates of Cryptococcus neoformans and Cryptococcus gattii species complexes from the National Invasive Fungal Surveillance Network of Uruguay.
来自乌拉圭全国侵袭性真菌监测网络的新型隐球菌和格特隐球菌种复合体的临床分离株的分子分型和抗真菌药敏性。
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JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome.JAK1功能获得性突变导致常染色体显性遗传的免疫失调和嗜酸性粒细胞增多综合征。
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