Jacob A S, Nielsen D H, Gianelly R E
Ann Emerg Med. 1985 Feb;14(2):159-60. doi: 10.1016/s0196-0644(85)81080-5.
A 29-year-old man with Wolff-Parkinson-White syndrome and atrial fibrillation developed fatal ventricular fibrillation shortly after receiving intravenous verapamil. The patient presented with an irregular pulse of 190. A total of 23 mg of verapamil was administered in small intravenous doses over 35 minutes. The ventricular rate accelerated as verapamil was administered, and fatal ventricular fibrillation followed. Three theoretical mechanisms by which verapamil may enhance conduction of atrial fibrillation in Wolff-Parkinson-White syndrome, predisposing to ventricular fibrillation, are mentioned.
一名患有预激综合征和心房颤动的29岁男性在静脉注射维拉帕米后不久发生致命性室颤。患者脉搏不规则，心率190次/分。在35分钟内分小剂量静脉注射了总共23毫克维拉帕米。注射维拉帕米时心室率加快，随后发生致命性室颤。文中提到了维拉帕米可能增强预激综合征患者心房颤动传导并易引发室颤的三种理论机制。
